1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Fexofenadine hydrochloride

Fexofenadine hydrochloride (Synonyms: MDL-16455 hydrochloride; Terfenadine carboxylate hydrochloride)

Cat. No.: HY-B0801A Purity: 99.70%
Handling Instructions

Fexofenadine hydrochloride (MDL-16455 hydrochloride), a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years).

For research use only. We do not sell to patients.

Fexofenadine hydrochloride Chemical Structure

Fexofenadine hydrochloride Chemical Structure

CAS No. : 153439-40-8

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
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50 mg USD 120 In-stock
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100 mg USD 240 In-stock
Estimated Time of Arrival: December 31
500 mg USD 800 In-stock
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Description

Fexofenadine hydrochloride (MDL-16455 hydrochloride), a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial (person aged ≥16 years)[1].

IC50 & Target

H1R[1]

In Vitro

Fexofenadine hydrochloride (MDL-16455 hydrochloride) (100 µM; 1 hour) effectively blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Nasal Fibroblasts
Concentration: 100 µM
Incubation Time: 1 hour
Result: Effectively blocked phosphorylated p38 activation in histamine-induced nasal fibroblasts.
In Vivo

Fexofenadine hydrochloride (MDL-16455 hydrochloride) (5-20 mg/kg; oral daily for 3 weeks) dose-dependently suppresses eosinophilia in C57BL/6 mice infected with T. spiralis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[1]
Dosage: 5, 10, 20 mg/kg
Administration: Orally; daily for 3 weeks
Result: Specifically dose-dependently suppressed eosinophilia in C57BL/6 mice infected with T. spiralis.
Clinical Trial
Molecular Weight

538.12

Formula

C₃₂H₄₀ClNO₄

CAS No.

153439-40-8

SMILES

O=C(O)C(C)(C)C1=CC=C(C(O)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (185.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8583 mL 9.2916 mL 18.5832 mL
5 mM 0.3717 mL 1.8583 mL 3.7166 mL
10 mM 0.1858 mL 0.9292 mL 1.8583 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

FexofenadineMDL-16455Terfenadine carboxylateMDL16455MDL 16455Histamine ReceptorInhibitorinhibitorinhibit

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Fexofenadine hydrochloride
Cat. No.:
HY-B0801A
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