2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. Fexofenadine hydrochloride

Fexofenadine hydrochloride  (Synonyms: MDL-16455 hydrochloride; Terfenadine carboxylate hydrochloride)

Cat. No.: HY-B0801A Purity: 99.86%
COA Handling Instructions

Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research.

For research use only. We do not sell to patients.

Fexofenadine hydrochloride Chemical Structure

Fexofenadine hydrochloride Chemical Structure

CAS No. : 153439-40-8

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10 mM * 1 mL in DMSO USD 61 In-stock
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10 mg USD 55 In-stock
50 mg USD 132 In-stock
100 mg USD 220 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Fexofenadine hydrochloride:

Fexofenadine hydrochloride Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3].

IC50 & Target[1]

H1 Receptor

 

In Vitro

Fexofenadine (1-100 µM; 1 h) inhibits the expression of IL-6 protein in nasal fibroblasts in a dose-dependent manner[2].
Fexofenadine (1-100 µM; 1 h) blocks phosphorylated p38 activation in histamine-induced nasal fibroblasts, but shows no effect on either pERK or pJNK[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fexofenadine hydrochloride Related Antibodies

Western Blot Analysis[2]

Cell Line: Nasal Fibroblasts
Concentration: 100 µM
Incubation Time: 1 hour
Result: Blocked pp38 activation in histamine-induced nasal fibroblasts, showed histamine-induced IL-6 production mediated by the p38 pathway.
In Vivo

Fexofenadine hydrochloride (oral administration; 5-20 mg/kg; once daily; 3 w) suppresses both eosinophilia and systemic anaphylaxis in C57BL/6 mice infected with T. spiralis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice infected with Trichinella spiralis[1]
Dosage: 5, 10 and 20 mg/kg
Administration: Oral administration; 5, 10 and 20 mg/kg; once daily; 3 weeks
Result: Inhibited eosinophilia in a dose-dependent manner.
Suppressed the decrease in rectal temperature (p<0.01), a marker for systemic anaphylaxis.
Clinical Trial
Molecular Weight

538.12

Appearance

Solid

Formula

C32H40ClNO4
CAS No.
SMILES

O=C(O)C(C)(C)C1=CC=C(C(O)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2)C=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (185.83 mM)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8583 mL 9.2916 mL 18.5832 mL
5 mM 0.3717 mL 1.8583 mL 3.7166 mL
10 mM 0.1858 mL 0.9292 mL 1.8583 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Fexofenadine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Fexofenadine153439-40-8MDL-16455Terfenadine carboxylateMDL16455MDL 16455Histamine Receptorallergic rhinitischronic idiopathic urticarialnasal fibroblastsInhibitorinhibitorinhibit

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