Hydroxyzine pamoate

Name: Hydroxyzine pamoate
Brand: MedChemExpress
SKU: HY-B0895
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0895 Purity: 99.85%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Hydroxyzine pamoate is a histamine receptor H1 antagonist, one of the salt forms of Hydroxyzine, soluble in dimethyl formamide and chloroform but insoluble in water and alcohol.

For research use only. We do not sell to patients.

Hydroxyzine pamoate Chemical Structure

CAS No. : 10246-75-0

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Hydroxyzine pamoate:

Hydroxyzine dihydrochloride In-stock
Hydroxyzine Get quote
Hydroxyzine-d₄ dihydrochloride Get quote
Hydroxyzine D4 Get quote
Hydroxyzine (pamoate) (Standard) Get quote

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H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Hydroxyzine pamoate is a histamine receptor H1 antagonist, one of the salt forms of Hydroxyzine, soluble in dimethyl formamide and chloroform but insoluble in water and alcohol^[1].

IC₅₀ & Target

H₁ Receptor

In Vivo

Hydroxyzine pamoate can be administered intravenously and orally^[2].
Hydroxyzine pamoate metabolite deschlorocycline induces congenital malformations^[4].
Example of configuring an oral suspension of Hydroxyzine pamoate 5 mg/mL: Hydroxyzine pamoate 850 mg, Xanthan gum 1 g, Propylene glycol 5 mL, Sorbic acid 200 mg, Sorbitol solution 20 mL, Flavor q.s., Syrup q.s. to 100 mL^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mature female pregnant rats weighing 240 g^[4]
Dosage:	100, 200 mg/kg
Administration:
Result:	Showed 100 mg/kg produced 25.7% and 42.9% deformed pups per kilogram of body weight; 200 mg/kg produced 100% deformed pups per kilogram of body weight.

Animal Model:	Dog received IV hydroxyzine dihydrochloride^[2][3]
Dosage:	2 mg/kg; daily; one day
Administration:	Intravenous injection (i.v.); Oral gavage (p.o.)
Result:	Showed that there was no significant difference at the 5% level in GWS (erythema×firmness×average diameter) between the two dosing methods.

Molecular Weight

763.27

Formula

C₄₄H₄₃ClN₂O₈

CAS No.

10246-75-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(O)C(CC2=C3C=CC=CC3=CC(C(O)=O)=C2O)=C4C=CC=CC4=C1)O.ClC5=CC=C(C(N6CCN(CCOCCO)CC6)C7=CC=CC=C7)C=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (327.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3102 mL	6.5508 mL	13.1015 mL
5 mM	0.2620 mL	1.3102 mL	2.6203 mL
10 mM	0.1310 mL	0.6551 mL	1.3102 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (2.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (2.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (248 KB) HNMR (249 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Tadiboyina Sirisha, et al. Enantioselective UFLC Determination of Hydroxyzine Enantiomers and Application to a Pharmacokinetic Study in Rabbits. J Chromatogr Sci. 2016 Nov;54(10):1806-1812. [Content Brief]

[2]. Petra Bizikova, et al. Blackwell Publishing Ltd Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs. Vet Dermatol. 1966 May 1;95(1):109-11. [Content Brief]

[3]. J L Barbet, et al. Duration of inhibition of immediate skin test reactivity by hydroxyzine hydrochloride in dogs. J Am Vet Med Assoc. 1989 Jun 1;194(11):1565-9. [Content Brief]

[4]. C T King, et al. Teratogenic effect of buclizine and hydroxyzine in the rat and chlorcyclizine in the mouse. Am J Obstet Gynecol. 1966 May 1;95(1):109-11. [Content Brief]

[5]. Loyd V, et al. Hydroxyzine Pamoate 5 mg/mL Oral Suspension. US Pharm. 2014;39(5):57-58.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3102 mL	6.5508 mL	13.1015 mL	32.7538 mL
	5 mM	0.2620 mL	1.3102 mL	2.6203 mL	6.5508 mL
	10 mM	0.1310 mL	0.6551 mL	1.3102 mL	3.2754 mL
	15 mM	0.0873 mL	0.4367 mL	0.8734 mL	2.1836 mL
	20 mM	0.0655 mL	0.3275 mL	0.6551 mL	1.6377 mL
	25 mM	0.0524 mL	0.2620 mL	0.5241 mL	1.3102 mL
	30 mM	0.0437 mL	0.2184 mL	0.4367 mL	1.0918 mL
	40 mM	0.0328 mL	0.1638 mL	0.3275 mL	0.8188 mL
	50 mM	0.0262 mL	0.1310 mL	0.2620 mL	0.6551 mL
	60 mM	0.0218 mL	0.1092 mL	0.2184 mL	0.5459 mL
	80 mM	0.0164 mL	0.0819 mL	0.1638 mL	0.4094 mL
	100 mM	0.0131 mL	0.0655 mL	0.1310 mL	0.3275 mL