1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. Histamine Receptor
  3. Hydroxyzine dihydrochloride

Hydroxyzine dihydrochloride 

Cat. No.: HY-B0548A Purity: 99.90%
Handling Instructions

Hydroxyzine dihydrochloride is a histamine H1-receptor antagonist.

For research use only. We do not sell to patients.

Hydroxyzine dihydrochloride Chemical Structure

Hydroxyzine dihydrochloride Chemical Structure

CAS No. : 2192-20-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 72 In-stock
Estimated Time of Arrival: December 31
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Description

Hydroxyzine dihydrochloride is a histamine H1-receptor antagonist. Target: Histamine H1-Receptor Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min [1]. Hydroxyzine dihydrochloride (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE) [2]. Hydroxyzine dihydrochloride (500 M) significantly increases transport of etoposide to the serosal site in the jejunal everted sacs. Hydroxyzine dihydrochloride significantly reduces the efflux and approximately 2.4 g/mL of etoposide in the jejunum and ileum. Hydroxyzine (0.2 μg/mL) significantly enhances the efflux of RH123 to the lumen [3]. Hydroxyzine dihydrochloride (500 μM) significantly decreases the steady-state etoposide concentration 2-fold, where the steady-state concentration reached about 0.055 μM/mL in Sprague-Dawley rats [3]. Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats [4].

Clinical Trial
Molecular Weight

447.83

Formula

C₂₁H₂₉Cl₃N₂O₂

CAS No.

2192-20-3

SMILES

ClC1=CC=C(C=C1)C(C2=CC=CC=C2)N3CCN(CCOCCO)CC3.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 150 mg/mL (334.95 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2330 mL 11.1650 mL 22.3299 mL
5 mM 0.4466 mL 2.2330 mL 4.4660 mL
10 mM 0.2233 mL 1.1165 mL 2.2330 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

HydroxyzineHistamine ReceptorInhibitorinhibitorinhibit

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Hydroxyzine dihydrochloride
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