1. Signaling Pathways
  2. NF-κB
  3. RANKL/RANK
  4. RANKL/RANK Inhibitor

RANKL/RANK Inhibitor

RANKL/RANK Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-N6973
    Boldine
    Inhibitor 99.57%
    Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research.
  • HY-P99966
    Narlumosbart
    Inhibitor
    Narlumosbart (JMT103) is an IgG4κ antibody targeting receptor activator of nuclear factor-κB ligand (RANKL).
  • HY-N10062
    Amakusamine
    Inhibitor
    Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC50 value of 10.5 μM in RAW264.7 cells.