Physalin D

Cat. No.: HY-N9912 Purity: 98.21%: Data Sheet
COA

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Physalin D is isolated from the aerial parts of Physalis angulate. Physalin D displays considerable cytotoxicity against several cancer cell lines, showing IC₅₀ values in the range of d 0.28 to 2.43 microg/mL. Physalin D has the potential for the cancer disease.

For research use only. We do not sell to patients.

Physalin D Chemical Structure

CAS No. : 54980-22-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Biological Activity
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 50 μM Compound: 20	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 35608269]
HepG2	IC₅₀	> 50 μM Compound: 20	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 35608269]
L02	IC₅₀	> 50 μM Compound: 20	Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 35608269]
MCF7	IC₅₀	> 50 μM Compound: 20	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 35608269]
RAW264.7	IC₅₀	49.8 μM Compound: 20	Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-stimulated NO production pretreated with LPS followed by compund addition by Griess reagent based microplate reader assay Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-stimulated NO production pretreated with LPS followed by compund addition by Griess reagent based microplate reader assay	[PMID: 35608269]
RAW264.7	IC₅₀	> 50 μM Compound: 20	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 35608269]
SGC-7901	IC₅₀	> 50 μM Compound: 20	Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 35608269]

Molecular Weight

544.55

Formula

C₂₈H₃₂O₁₁

CAS No.

54980-22-2

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@]34[C@]5([H])[C@]6([C@@](C(O[C@@H]2C6)=O)([H])CO[C@](C5=O)([C@@]7([H])[C@]([C@@]8([C@@]([C@@H](C7)O)(CC=CC8=O)O)C)([H])CC[C@@]4(C(O1)=O)O)O3)C

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 98.21%

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Data Sheet (284 KB) SDS (252 KB)

COA (272 KB) HNMR (79 KB) CNMR (90 KB) RP-HPLC (89 KB)

Handling Instructions (2659 KB)

References

[1]. Magalhães HI, et al. In-vitro and in-vivo antitumour activity of physalins B and D from Physalis angulata. J Pharm Pharmacol. 2006;58(2):235-241. [Content Brief]

[2]. Xiang D, Zou J, Zhu X, et al. Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling. Phytomedicine. 2020;78:153294. [Content Brief]

[3]. Ding N, Lu Y, Cui H, et al. Physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via regulating calcium signaling. BMB Rep. 2020;53(3):154-159. [Content Brief]

[4]. Ding N, Wang Y, Dou C, et al. Physalin D regulates macrophage M1/M2 polarization via the STAT1/6 pathway. J Cell Physiol. 2019;234(6):8788-8796. [Content Brief]

Physalin D Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Physalin D54980-22-2TGF-beta/SmadRANKL/RANKSTATTransforming growth factor betaaerial partsPhysalis angulatecytotoxicitycancerInhibitorinhibitorinhibit

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Physalin D

Physalin D Related Antibodies

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Biological Activity

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Physalin D Related Classifications

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