Art. -Nr.: HY-100330

YM348

Name: YM348
Brand: MedChemExpress
SKU: HY-100330
Price: 400.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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YM348 is a potent and orally active 5-HT_2C receptor agonist, which shows a high affinity for cloned human 5-HT_2C receptor (K_i: 0.89 nM).

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Reinheit : 98.89%
CAS. Nr.: 372163-84-3
Formel: C₁₄H₁₇N₃O
Molecular Weight:243.30

Speicherung:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

YM348 Chemical Structure

CAS. Nr.: 372163-84-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

YM348 is a potent and orally active 5-HT_2C receptor agonist, which shows a high affinity for cloned human 5-HT_2C receptor (K_i: 0.89 nM).

IC₅₀ & Target

^[1]

5-HT_2C Receptor

0.89 nM (Ki)

5-HT_2C Receptor

5-HT_2B Receptor

2.5 nM (Ki)

5-HT_2A Receptor

13 nM (Ki)

5-HT_2C Receptor

1 nM (EC₅₀)

5-HT_2B Receptor

3.2 nM (EC₅₀)

5-HT_2A Receptor

93 nM (EC₅₀)

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	1 nM Compound: 7i, YM348	Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis Agonist activity at human cloned 5HT2C receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	[PMID: 18035544]
CHO	EC₅₀	93 nM Compound: 7i, YM348	Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis Agonist activity at human cloned 5HT2A receptor expressed in CHO cells assessed as myo-[3H]inositol hydrolysis	[PMID: 18035544]
HEK293-EBNA	EC₅₀	3.2 nM Compound: 7i, YM348	Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis Agonist activity at human cloned 5HT2B receptor expressed in HEK293-EBNA cells assessed as myo-[3H]inositol hydrolysis	[PMID: 18035544]

In Vitro

YM348 has high affinity for cloned human 5-HT_2C receptors with a K_i value of 0.89 nM and lower affinities for human-cloned 5-HT_2B (K_i: 2.5 nM) and 5-HT_2A receptors (K_i: 13 nM). To assess the binding specificity of YM348, a broad evaluation of an additional 46 binding sites including several other 5-HT receptor subtypes (1A, 1B, 1D, 3, 4, 5A, 6, 7) is performed. IC₅₀ values of YM348 are found to be >1 μM for all of the binding sites except for the human 5-HT_1A receptors (K_i: 130 nM), bovine 5-HT_1D receptors (K_i: 481 nM), human 5-HT₇ receptors (K_i: 177 nM), and human α_2A receptors (K_i: 126 nM).YM348 exhibits a full-agonistic activity on human 5-HT_2A and 5-HT_2B receptors. The EC₅₀ values of YM348 for 5-HT_2C, 5-HT_2A, and 5-HT_2B receptors are 1.0, 93 and 3.2 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Oral administration of YM348 induces penile erections and hypolocomotion in rats, being completely inhibited by a selective 5-HT_2C receptor antagonist, SB242084. YM348 inhibits spontaneous activity in a dose-dependent manner with a minimum effective dose of 0.203 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 372163-84-3
Appearance Oil
Molecular Weight 243.30
Formel C₁₄H₁₇N₃O
Color Light yellow to brown
SMILES

C[C@H](N)CN(N=C1)C2=C1C=CC3=C2C=C(CC)O3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Journal Impact Factor

J Affect Disord

Uncoupling serotonin (2C) and dopamine (D2) receptor heterodimers ameliorate PTSD-like behaviors. [Abstract]

2025 Mar 21:S0165-0327(25)00475-6. PMID: 40122260

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (411.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.1102 mL

20.5508 mL

41.1015 mL

5 mM

0.8220 mL

4.1102 mL

8.2203 mL

10 mM

0.4110 mL

2.0551 mL

4.1102 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (10.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (10.28 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kimura Y, et al. Pharmacological profile of YM348, a novel, potent and orally active 5-HT_2C receptor agonist. Eur J Pharmacol. 2004 Jan 1;483(1):37-43. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.1102 mL	20.5508 mL	41.1015 mL	102.7538 mL
	5 mM	0.8220 mL	4.1102 mL	8.2203 mL	20.5508 mL
	10 mM	0.4110 mL	2.0551 mL	4.1102 mL	10.2754 mL
	15 mM	0.2740 mL	1.3701 mL	2.7401 mL	6.8503 mL
	20 mM	0.2055 mL	1.0275 mL	2.0551 mL	5.1377 mL
	25 mM	0.1644 mL	0.8220 mL	1.6441 mL	4.1102 mL
	30 mM	0.1370 mL	0.6850 mL	1.3701 mL	3.4251 mL
	40 mM	0.1028 mL	0.5138 mL	1.0275 mL	2.5688 mL
	50 mM	0.0822 mL	0.4110 mL	0.8220 mL	2.0551 mL
	60 mM	0.0685 mL	0.3425 mL	0.6850 mL	1.7126 mL
	80 mM	0.0514 mL	0.2569 mL	0.5138 mL	1.2844 mL
	100 mM	0.0411 mL	0.2055 mL	0.4110 mL	1.0275 mL

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YM348

Publications Citing Use of MedChemExpress (MCE) YM348

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen