L-Hydroxyproline
Based on 2 publication(s) in Google Scholar
L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
For research use only. We do not sell to patients.
- Purity : 99.89%
- CAS No.: 51-35-4
- Formula: C5H9NO3
- Molecular Weight:131.13
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Hydroxyproline
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
Description
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
L-Hydroxyproline (Trans-4-hydroxy-L-proline;Trans-Hyp) has been widely used in medicine, biochemistry, food, cosmetic and other aspects of industry. Additionally, L-Hydroxyproline has also been found in the composition of some secondary metabolites such as actinomycins and echinocandins. L-Hydroxyproline is manufactured industrially most by acid hydrolysis of mammalian collagen because of its rich amount in the collagen[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 51-35-4
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Appearance Solid
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Molecular Weight 131.13
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Formula C5H9NO3
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Color White to off-white
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SMILES
O=C(O)[C@H](C1)NC[C@@H]1O
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Synonyms
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Biochem Pharmacol
Discovery of targeting USP10-mediated proline metabolism arrangement to inhibit hepatocellular carcinoma progression. [Abstract]2025 Jun:236:116904. PMID: 40158816
Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (381.30 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (762.60 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.6260 mL | 38.1301 mL | 76.2602 mL | 190.6505 mL |
| 5 mM | 1.5252 mL | 7.6260 mL | 15.2520 mL | 38.1301 mL | |
| 10 mM | 0.7626 mL | 3.8130 mL | 7.6260 mL | 19.0650 mL | |
| 15 mM | 0.5084 mL | 2.5420 mL | 5.0840 mL | 12.7100 mL | |
| 20 mM | 0.3813 mL | 1.9065 mL | 3.8130 mL | 9.5325 mL | |
| 25 mM | 0.3050 mL | 1.5252 mL | 3.0504 mL | 7.6260 mL | |
| 30 mM | 0.2542 mL | 1.2710 mL | 2.5420 mL | 6.3550 mL | |
| 40 mM | 0.1907 mL | 0.9533 mL | 1.9065 mL | 4.7663 mL | |
| 50 mM | 0.1525 mL | 0.7626 mL | 1.5252 mL | 3.8130 mL | |
| 60 mM | 0.1271 mL | 0.6355 mL | 1.2710 mL | 3.1775 mL | |
| 80 mM | 0.0953 mL | 0.4766 mL | 0.9533 mL | 2.3831 mL | |
| 100 mM | 0.0763 mL | 0.3813 mL | 0.7626 mL | 1.9065 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Hydroxyproline Related Classifications
HY-40135 Related Classifications
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