L-Hydroxyproline-d4
Based on 1 Customer Validation
L-Hydroxyproline-d4 is deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 2734920-51-3
- Formula: C5H5D4NO3
- Molecular Weight:135.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2734920-51-3
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Unlabeled Cas 51-35-4
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Appearance Solid
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Molecular Weight 135.15
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Formula C5H5D4NO3
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Color White to off-white
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SMILES
O[C@]1(C([2H])(N[C@](C(O)=O)(C1)[2H])[2H])[2H]
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Synonyms
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 50 mg/mL (369.96 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.3992 mL | 36.9959 mL | 73.9919 mL | 184.9797 mL |
| 5 mM | 1.4798 mL | 7.3992 mL | 14.7984 mL | 36.9959 mL | |
| 10 mM | 0.7399 mL | 3.6996 mL | 7.3992 mL | 18.4980 mL | |
| 15 mM | 0.4933 mL | 2.4664 mL | 4.9328 mL | 12.3320 mL | |
| 20 mM | 0.3700 mL | 1.8498 mL | 3.6996 mL | 9.2490 mL | |
| 25 mM | 0.2960 mL | 1.4798 mL | 2.9597 mL | 7.3992 mL | |
| 30 mM | 0.2466 mL | 1.2332 mL | 2.4664 mL | 6.1660 mL | |
| 40 mM | 0.1850 mL | 0.9249 mL | 1.8498 mL | 4.6245 mL | |
| 50 mM | 0.1480 mL | 0.7399 mL | 1.4798 mL | 3.6996 mL | |
| 60 mM | 0.1233 mL | 0.6166 mL | 1.2332 mL | 3.0830 mL | |
| 80 mM | 0.0925 mL | 0.4624 mL | 0.9249 mL | 2.3122 mL | |
| 100 mM | 0.0740 mL | 0.3700 mL | 0.7399 mL | 1.8498 mL |
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