L-Hydroxyproline-d3
Based on 1 Customer Validation
L-Hydroxyproline-d3 is the deuterium labeled L-Hydroxyproline. L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 1356016-86-8
- Formula: C5H6D3NO3
- Molecular Weight:134.15
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1356016-86-8
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Unlabeled Cas 51-35-4
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Appearance Solid
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Molecular Weight 134.15
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Formula C5H6D3NO3
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Color White to off-white
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SMILES
O=C(O)[C@@](C1)([2H])NC([2H])([2H])[C@@H]1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 50 mg/mL (372.72 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 7.4543 mL | 37.2717 mL | 74.5434 mL | 186.3586 mL |
| 5 mM | 1.4909 mL | 7.4543 mL | 14.9087 mL | 37.2717 mL | |
| 10 mM | 0.7454 mL | 3.7272 mL | 7.4543 mL | 18.6359 mL | |
| 15 mM | 0.4970 mL | 2.4848 mL | 4.9696 mL | 12.4239 mL | |
| 20 mM | 0.3727 mL | 1.8636 mL | 3.7272 mL | 9.3179 mL | |
| 25 mM | 0.2982 mL | 1.4909 mL | 2.9817 mL | 7.4543 mL | |
| 30 mM | 0.2485 mL | 1.2424 mL | 2.4848 mL | 6.2120 mL | |
| 40 mM | 0.1864 mL | 0.9318 mL | 1.8636 mL | 4.6590 mL | |
| 50 mM | 0.1491 mL | 0.7454 mL | 1.4909 mL | 3.7272 mL | |
| 60 mM | 0.1242 mL | 0.6212 mL | 1.2424 mL | 3.1060 mL | |
| 80 mM | 0.0932 mL | 0.4659 mL | 0.9318 mL | 2.3295 mL | |
| 100 mM | 0.0745 mL | 0.3727 mL | 0.7454 mL | 1.8636 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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