(R)-3-Hydroxybutanoic acid (Synonyms: (R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid)

Name: (R)-3-Hydroxybutanoic acid
Brand: MedChemExpress
SKU: HY-W051723
Rating: 5.0 (6 reviews)

Cat. No.: HY-W051723 Pureza: 97.65%: Ficha de datos
COA

SDS
Instrucciones de manejo
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(R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones.

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No. CAS : 625-72-9

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid or liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid or liquid
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 6 publication(s) in Google Scholar

Other Forms of (R)-3-Hydroxybutanoic acid:

3-Hydroxybutyric acid In-stock
(3R)-3-Hydroxybutyric acid-1-¹³C In-stock
(R)-3-Hydroxybutanoic acid sodium In-stock
(R)-3-Hydroxybutanoic acid-d Obtener un presupuesto
(R)-3-Hydroxybutanoic acid (Standard) Obtener un presupuesto

6 Publications Citing Use of MCE (R)-3-Hydroxybutanoic acid

Bio/Physico-chemical Assay

RT-PCR

Cell Imaging/Staining

ELISA

Histological Imaging/Staining

: (R)-3-Hydroxybutanoic acid purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 May 31;10(22):eadk5011. [Abstract]; (R)-3-Hydroxybutanoic acid (3-HB) (0.5 mM; 6-24 h) significantly up-regulated the mRNA levels of Gpld1 in HepG2 cells.

: (R)-3-Hydroxybutanoic acid purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 May 31;10(22):eadk5011. [Abstract]; (R)-3-Hydroxybutanoic acid (3-HB) (0.5 mM; 6-24 h) significantly up-regulated the protein level of Gpld1 in HepG2 cells.

: (R)-3-Hydroxybutanoic acid purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 May 31;10(22):eadk5011. [Abstract]; Fluorescence microscopy of VSV-GFP viruses in HepG2 cells treated with PBS (Ctrl) or (R)-3-Hydroxybutanoic acid (3-HB) (5 mM) for 24 hours and then infected with VSV-GFP (MOI = 1.0; 24 hours). Scale bars, 200 μm.

: (R)-3-Hydroxybutanoic acid purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 May 31;10(22):eadk5011. [Abstract]; ELISA analysis of mIFN-β protein levels in the serum of mice administrated with (R)-3-Hydroxybutanoic acid (3-HB) (3 mmol/kg, i.v.) or PBS (Ctrl) for 24 hours. The results showed that 3-HB administration up-regulated serum IFN-I levels.

: (R)-3-Hydroxybutanoic acid purchased from MedChemExpress. Usage Cited in: Sci Adv. 2024 May 31;10(22):eadk5011. [Abstract]; HE staining of the livers from Gpld1^+/+ and Gpld1−/− mice was performed. Gpld1^+/+ and Gpld1−/− mice were administrated with (R)-3-Hydroxybutanoic acid (3-HB) (3 mmol/kg; i.v.) or PBS for 24 hours, and then infected with VSV (1 × 10⁸ PFU/g of body weight; intranasal) for 48 hours. Scale bar: 100 μm.

: (R)-3-Hydroxybutanoic acid purchased from MedChemExpress. Usage Cited in: Am J Physiol Cell Physiol. 2024 Jun 1;326(6):C1710-C1720. [Abstract]; Exposure to 3 mM (R)-3-Hydroxybutanoic acid sodium (d-βOHB, 3 h) increased basal glucose uptake, significantly higher than in the glucose, substrate-free, and 3 mM 1-βOHB groups.

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Descripciòn

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vitro

(R)-3-Hydroxybutanoic acid (D-3-Hydroxybutyric acid) is a metabolite, and converted from acetoacetic acid. Enhanced hepatic fatty acid oxidation results in the increased production of acetoacetic acid which is in turn converted to (R)-3-Hydroxybutanoic acid by a reaction catalyzed by 3-hydroxybutyrate dehydrogenase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

104.10

Fòrmula

C₄H₈O₃

No. CAS

625-72-9

Appearance

<49°C Solid,>50°C Liquid

Color

Colorless to off-white

SMILES

C[C@@H](O)CC(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

H₂O : 100 mg/mL (960.61 mM; Need ultrasonic)

DMSO : 100 mg/mL (960.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.6061 mL	48.0307 mL	96.0615 mL
5 mM	1.9212 mL	9.6061 mL	19.2123 mL
10 mM	0.9606 mL	4.8031 mL	9.6061 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (24.02 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (24.02 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (24.02 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (960.61 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 97.65%

Select Batch:

Ficha de datos (273 KB) SDS (394 KB)

COA (247 KB) HNMR (132 KB) GC (181 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Ide T. Enzymatic-HPLC method to analyze D-3-hydroxybutyric acid in rat serum. Biosci Biotechnol Biochem. 2010;74(8):1578-82. [Content Brief]

[2]. Mateusz Biernacki, et al. Production of (R)-3-hydroxybutyric acid by Arxula adeninivorans. AMB Express. 2017 Dec;7(1):4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	9.6061 mL	48.0307 mL	96.0615 mL	240.1537 mL
	5 mM	1.9212 mL	9.6061 mL	19.2123 mL	48.0307 mL
	10 mM	0.9606 mL	4.8031 mL	9.6061 mL	24.0154 mL
	15 mM	0.6404 mL	3.2020 mL	6.4041 mL	16.0102 mL
	20 mM	0.4803 mL	2.4015 mL	4.8031 mL	12.0077 mL
	25 mM	0.3842 mL	1.9212 mL	3.8425 mL	9.6061 mL
	30 mM	0.3202 mL	1.6010 mL	3.2020 mL	8.0051 mL
	40 mM	0.2402 mL	1.2008 mL	2.4015 mL	6.0038 mL
	50 mM	0.1921 mL	0.9606 mL	1.9212 mL	4.8031 mL
	60 mM	0.1601 mL	0.8005 mL	1.6010 mL	4.0026 mL
	80 mM	0.1201 mL	0.6004 mL	1.2008 mL	3.0019 mL
	100 mM	0.0961 mL	0.4803 mL	0.9606 mL	2.4015 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(R)-3-Hydroxybutanoic acid Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-3-Hydroxybutanoic acid625-72-9(R)-(-)-3-Hydroxybutanoic acid (R)-3-Hydroxybutyric acidEndogenous MetaboliteInhibitorinhibitorinhibit

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(R)-3-Hydroxybutanoic acid (Synonyms: (R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid)

Revisión del cliente

Other Forms of (R)-3-Hydroxybutanoic acid:

(R)-3-Hydroxybutanoic acid Related Antibodies

6 Publications Citing Use of MCE (R)-3-Hydroxybutanoic acid

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Endogenous Metabolite:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

(R)-3-Hydroxybutanoic acid Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

(R)-3-Hydroxybutanoic acid Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

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SAFETY DATA SHEET (SDS)

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