2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Antibiotic Endogenous Metabolite
  4. Actinomycin D1

Actinomycin D1 is an Actinomycin-class Antibacterial agent. Actinomycin D1 is isolated from the fermentation broth of sponge-associated marine Streptomyces sp. LHW52447. Actinomycin D1 potently inhibits the growth of MRSA strains P172, P175 and ATCC 33591, with MIC values of 0.125 μg/mL, 0.25 μg/mL and 0.125 μg/mL, respectively. Actinomycin D1 can be used in studies related to MRSA infections.

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Actinomycin D1

Actinomycin D1 Chemical Structure

CAS No. : 72766-92-8

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Actinomycin D1 Related Antibodies

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Description

Actinomycin D1 is an Actinomycin-class Antibacterial agent. Actinomycin D1 is isolated from the fermentation broth of sponge-associated marine Streptomyces sp. LHW52447. Actinomycin D1 potently inhibits the growth of MRSA strains P172, P175 and ATCC 33591, with MIC values of 0.125 μg/mL, 0.25 μg/mL and 0.125 μg/mL, respectively. Actinomycin D1 can be used in studies related to MRSA infections[1].

IC50 & Target[1]

Fungal Metabolite

 

In Vitro

Actinomycin D1 (0-64 μg/mL; 24 h) potently inhibits the growth of MRSA strains P172, P175, and ATCC 33591 with MIC values of 0.125 μg/mL, 0.25 μg/mL, and 0.125 μg/mL, respectively[1].
Actinomycin D1 (0.1-30 μM; 48 h) exhibits cytotoxicity against WI-38 cells with an IC50 of 74 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Actinomycin D1 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: WI-38 human diploid lung fibroblasts
Concentration: 0.1-30 μM
Incubation Time: 48 h
Result: Reduced WI-38 cell viability with an IC50 of 74 μM.
Molecular Weight

1427.60

Formula

C69H98N14O19
CAS No.
SMILES

O=C(C1=CC(NC(COC([C@H](C(C)C)N)=O)=O)=C(C)C(O2)=C1N=C(C(C(N[C@@H]3C(N[C@@H](C(C)C)C(N4CCC[C@H]4C(N(CC(N([C@@H](C(C)C)C(O[C@@H]3C)=O)C)=O)C)=O)=O)=O)=O)=C5N)C2=C(C)C5=O)N[C@@H]6C(N[C@@H](C(C)C)C(N7CCC[C@H]7C(N(CC(N([C@@H](C(C)C)C(O[C@@H]6C)=O)C)=O)C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Actinomycin D1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Actinomycin D172766-92-8Actinomycin D 1Actinomycin D-1BacterialAntibioticEndogenous MetaboliteMRSAmethicillin-resistant Staphylococcus aureushuman diploid lung fibroblastsWI-38Streptomyces sp. LHW52447Inhibitorinhibitorinhibit

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