アテノロール (Synonyms: Atenolol; (RS)-Atenolol)

Name: Atenolol
Brand: MedChemExpress
SKU: HY-17498
Rating: 5.0 (21 reviews)

製品番号: HY-17498 純度: 98.85%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 29122-68-7

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solid
500 mg	$50	在庫あり	Estimated Time of Arrival: December 31
1 g	$64	在庫あり	Estimated Time of Arrival: December 31
5 g	$161	在庫あり	Estimated Time of Arrival: December 31
10 g		お問い合わせ
50 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 21 publication(s) in Google Scholar

Other Forms of Atenolol:

(S)-Atenolol 在庫あり
Atenolol-d₇ 在庫あり
Atenolol (Standard) 在庫あり
Atenolol-d₆ お問い合わせ
Atenolol-¹³C₆ お問い合わせ

顧客検証

Cell Proliferation/Viability Assay

Bio/Physico-chemical Assay

Flow Cytometry

Cell Imaging/Staining

: Atenolol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]; Atenolol (ATN, 1 µM, 72 h) rescued the Norepinephrine (NE, 10 µM)-induced decrease in TM4 cell viability.

: Atenolol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]; Atenolol (ATN, 1 µM, 48 h) restored the Norepinephrine (NE, 10 µM)-induced increase in intracellular ferrous ion concentration in TM4 cells.

: Atenolol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]; Atenolol (ATN, 1 µM, 48 h) restored the Norepinephrine (NE, 10 µM)-induced decrease in mitochondrial membrane potential in TM4 cells.

: Atenolol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]; Atenolol (ATN, 1 µM, 48 h) reversed Norepinephrine (NE,10 μM）-induced alterations in the expression of SLC7A11, GPX4, and ACSL4 in TM4 cells.

: Atenolol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Oct 6:e04817. [Abstract]; Atenolol (ATN, 1 µM, 48 h) reversed Norepinephrine (NE,10 μM）-induced alterations in the expression of SLC7A11, GPX4, and ACSL4 in TM4 cells.

Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

α adrenergic receptor β adrenergic receptor

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

Beta-1 adrenergic receptor

697 nM (Ki)

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	>100 3 Compound: Atenolol	Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 32216987]
A-375	IC₅₀	> 100 3 Compound: Atenolol	Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 32216987]
A-375	IC₅₀	> 100 3 Compound: Atenolol	Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human A375 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 32216987]
HEK293	IC₅₀	2.1 × 10^-7 41 Compound: Atenolol	Displacement of [3H](-)CGP12177 from human recombinant Beta-1 adrenergic receptor expressed in HEK293 cells Displacement of [3H](-)CGP12177 from human recombinant Beta-1 adrenergic receptor expressed in HEK293 cells	[PMID: 26988801]
HEK293	IC₅₀	2.1 x 10^-1 3 Compound: Atenolol	Displacement of [3H]CGP 12177 from human recombinant beta1 adrenergic receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method Displacement of [3H]CGP 12177 from human recombinant beta1 adrenergic receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method	[PMID: 27876250]
HEK293	IC₅₀	2.1 × 10^-7 41 Compound: Atenolol	Displacement of [3H]CGP 12177 from human recombinant beta1 adrenergic receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method Displacement of [3H]CGP 12177 from human recombinant beta1 adrenergic receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method	[PMID: 27876250]
SK-MEL-28	IC₅₀	> 100 3 Compound: Atenolol	Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 32216987]
SK-MEL-28	IC₅₀	>100 3 Compound: Atenolol	Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 32216987]
SK-MEL-5	IC₅₀	> 100 3 Compound: Atenolol	Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 32216987]
SK-MEL-5	IC₅₀	>100 3 Compound: Atenolol	Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 32216987]
HEK293	IC₅₀	2.1 x 10^-7 41 Compound: Atenolol	Displacement of [3H](-)CGP12177 from human recombinant Beta-1 adrenergic receptor expressed in HEK293 cells Displacement of [3H](-)CGP12177 from human recombinant Beta-1 adrenergic receptor expressed in HEK293 cells	[PMID: 26988801]
HEK293	IC₅₀	2.1 x 10^-7 41 Compound: Atenolol	Displacement of [3H]CGP 12177 from human recombinant beta1 adrenergic receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method Displacement of [3H]CGP 12177 from human recombinant beta1 adrenergic receptor expressed in HEK293 cells measured after 60 mins by scintillation counting method	[PMID: 27876250]
SK-MEL-28	IC₅₀	> 100 3 Compound: Atenolol	Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 32216987]
SK-MEL-5	IC₅₀	> 100 3 Compound: Atenolol	Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Antiproliferative activity against human SK-MEL-5 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 32216987]

体外実験

Atenolol (1-100 μM, 5 h) strengthenes the inhibitory effect on cell migration of rat aortic smooth muscle cells when combinated with Nifedipine (HY-B0284) (1-100μM)^[3].
Atenolol (50-150 μM, 24 h) decreases the cell surival of Hem-ECs in a dose-dependent manner^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[3]

Cell Line:	Rat aortic smooth muscle cells
Concentration:	1-100 μM
Incubation Time:	48-72 h
Result:	Inhibited cell proliferation (-20%) when incubation lasted 72 h at 100 μM.

Cell Migration Assay ^[3]

Cell Line:	Rat aortic smooth muscle cells
Concentration:	1-100 μM
Incubation Time:	5 h
Result:	Inhibited myocyte migration induced by fibrinogen in a dose-dependent manner.

Western Blot Analysis^[4]

Cell Line:	Hemangioma-derived ECs (Hem-ECs)
Concentration:	100 μM
Incubation Time:	6 h
Result:	Increased LC3-Ⅱ/LC3-Ⅰ ratio and decreased p62.

体内実験

Atenolol (5-20 mg/kg, i.g., one time) combinated with Amlodipine (HY-B0317) can reduce and stabilize blood oressure (BP) in 2K1C renovascular hypertensive rats^[5].
Atenolol (6 mg/kg, p.o., one time) combinated with Nifedipine (HY-B0284) prevents ZD6126-induced cardiac necrosis and increases plasma troponin T levels^[6].
Atenolol (40 mg/kg, p.o., daily, 6 weeks) increased plasma membrane β₁- and β₂- adrenoceptors density in rats^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	2K1C renovascular hypertensive rats ^[5]
Dosage:	5-20 mg/kg (single; combination with Amlodipine (HY-B0317) (0.5-2 mg/kg))
Administration:	i.g., one time
Result:	Reduced the average blood oressure (BP) levels within 24 h after administration when treated with Atenolol and Amlodipine (HY-B0317). Decreased the blood pressure variability (BPV) levels when treated with 10 mg/kg Atenolol and 1 mg/kg Amlodipine (HY-B0317), or 20 mg/kg Atenolol and 2 mg/kg Amlodipine (HY-B0317).

Animal Model:	Hras5 tumor xenograft rat model ^[6]
Dosage:	6 mg/kg (combination with Nifedipine (HY-B0284) (10 mg/kg))
Administration:	Oral gavage (p.o.), one time
Result:	Abolished the hypertensive and tachycaidic effects of ZD6126.

Animal Model:	Male wistar rats^[7]
Dosage:	40 mg/kg
Administration:	Oral gavage (p.o.), daily, 6 weeks
Result:	Increased the density of total β-adrenoceptors. Decreased the expression level of β₁- adrenoceptor mRNA.

分子量

266.34

分子式

C₁₄H₂₂N₂O₃

CAS 番号

29122-68-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(N)CC1=CC=C(OCC(O)CNC(C)C)C=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (375.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 8.33 mg/mL (31.28 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7546 mL	18.7730 mL	37.5460 mL
5 mM	0.7509 mL	3.7546 mL	7.5092 mL
10 mM	0.3755 mL	1.8773 mL	3.7546 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 36.67 mg/mL (137.68 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 98.85%

Select Batch:

データシート (277 KB) SDS (393 KB)

COA (243 KB) RP-HPLC (278 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Heel RC, et al. Atenolol: a review of its pharmacological properties and therapeutic efficacy in angina pectoris and hypertension. Drugs. 1979;17(6):425-460. [Content Brief]

[2]. Engel G, et al. (+/-)[125Iodo] cyanopindolol, a new ligand for beta-adrenoceptors: identification and quantitation of subclasses of beta-adrenoceptors in guinea pig. Naunyn Schmiedebergs Arch Pharmacol. 1981;317(4):277-285. [Content Brief]

[3]. Corsini A, et al. Effect of the nifedipine-atenolol association on arterial myocyte migration and proliferation. Pharmacol Res. 1993 May-Jun;27(4):299-307. [Content Brief]

[4]. Lorusso B, et al. Β-blockers activate autophagy on infantile hemangioma-derived endothelial cells in vitro. Vascul Pharmacol. 2022 Oct;146:107110 [Content Brief]

[5]. Shen FM, et al. Synergistic effects of atenolol and amlodipine for lowering and stabilizing blood pressure in 2K1C renovascular hypertensive rats. Acta Pharmacol Sin. 2005 Nov;26(11):1303-8. [Content Brief]

[6]. Gould S, et al. Effect of pretreatment with atenolol and nifedipine on ZD6126-induced cardiac toxicity in rats. J Natl Cancer Inst. 2007 Nov 21;99(22):1724-8. [Content Brief]

[7]. Horinouchi T, et al. Different changes of plasma membrane beta-adrenoceptors in rat heart after chronic administration of propranolol, atenolol and bevantolol. Life Sci. 2007 Jul 12;81(5):399-404. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	3.7546 mL	18.7730 mL	37.5460 mL	93.8650 mL
	5 mM	0.7509 mL	3.7546 mL	7.5092 mL	18.7730 mL
	10 mM	0.3755 mL	1.8773 mL	3.7546 mL	9.3865 mL
	15 mM	0.2503 mL	1.2515 mL	2.5031 mL	6.2577 mL
	20 mM	0.1877 mL	0.9386 mL	1.8773 mL	4.6932 mL
	25 mM	0.1502 mL	0.7509 mL	1.5018 mL	3.7546 mL
	30 mM	0.1252 mL	0.6258 mL	1.2515 mL	3.1288 mL
DMSO	40 mM	0.0939 mL	0.4693 mL	0.9386 mL	2.3466 mL
	50 mM	0.0751 mL	0.3755 mL	0.7509 mL	1.8773 mL
	60 mM	0.0626 mL	0.3129 mL	0.6258 mL	1.5644 mL
	80 mM	0.0469 mL	0.2347 mL	0.4693 mL	1.1733 mL
	100 mM	0.0375 mL	0.1877 mL	0.3755 mL	0.9386 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Atenolol Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atenolol29122-68-7(RS)-AtenololAdrenergic ReceptorBeta ReceptorHypertensionangina pectorisβ1-adrenergic receptorcardioselectiveHem-ECsInhibitorinhibitorinhibit

日本の代理先をお選びくださいナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
製品名			カスタマ需要量 *
お名前 *			タイトル
メールアドレス *			電話番号 *
デパートメント			組纖名 *
市区町村			都道府県
国或いは地域 *
必ず会社名を記載ください。個人への返信は行いません。
備考

製品名			Lot #
お名前 *			メールアドレス *
電話番号 *			部門 *
組纖名 *			国或いは地域 *
備考

アテノロール (Synonyms: Atenolol; (RS)-Atenolol)

カスタマーレビュー

Other Forms of Atenolol:

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Atenolol Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

お名前
メール *

	Sorry, but the email address you supplied was invalid.

アテノロール (Synonyms: Atenolol; (RS)-Atenolol)

カスタマーレビュー

Other Forms of Atenolol:

アテノロール 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

Adrenergic Receptor アイソフォーム固有の製品をすべて表示:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

アテノロール 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Atenolol Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

カスタマーレビュー

Request for HNMR Report

Request for HNMR Report

アテノロール関連抗体

アテノロール関連抗体