Caspofungin (Synonyms: MK-0991; L-743872)

Name: Caspofungin
Brand: MedChemExpress
SKU: HY-17006A
Rating: 5.0 (10 reviews)

Cat. No.: HY-17006A Purity: 99.50%: Data Sheet
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Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No. : 162808-62-0

사이즈	재고	수량
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 10 publication(s) in Google Scholar

Other Forms of Caspofungin:

Caspofungin-d₄ In-stock
Caspofungin diacetate In-stock

10 Publications Citing Use of MCE Caspofungin

In Vivo Efficacy Study

Microbiological Assay

Histological Imaging/Staining

Cell Proliferation/Viability Assay

: Caspofungin purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2025 Dec:167:109253. [Abstract]; Caspofungin (5 mg/kg; i.g.; once daily for 8 d) treatment effectively alleviated the atrophy of thymus and spleen in mice.

: Caspofungin purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2025 Dec:167:109253. [Abstract]; Caspofungin (5 mg/kg; i.g.; once daily for 8 d) treatment enabled C57BL/6 mice infected with C. albicans ATCC14053-FR to maintain their body weight.

: Caspofungin purchased from MedChemExpress. Usage Cited in: Bioorg Chem. 2025 Dec:167:109253. [Abstract]; HE-stained and PASM-stained sections of kidneys and lungs after treatment. Caspofungin (5 mg/kg; i.g.; once daily for 8 d) diminished lesion areas, reduced inflammatory cell infiltration, and significantly improved renal tubular damage and alveolar edema.

: Caspofungin purchased from MedChemExpress. Usage Cited in: Front Microbiol. 2024 Jul 30:15:1450557. [Abstract]; Caspofungin (50 μg; 30 ℃; 2 d) showed clear ZOI for wild-type strain SC5314 and two strains bearing ChrR trisomy and tetrasomy.

: Caspofungin purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2016 Aug 12;39(3):939-949. [Abstract]; Arithmetic means±SEM (n=21) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Caspofungin (30-60 µg/mL).

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	> 100 μg/mL Compound: Caspofungin	Cytotoxicity against human HeLa cells after 48 hrs by SRB assay Cytotoxicity against human HeLa cells after 48 hrs by SRB assay	[PMID: 26848627]
HepG2	CC₅₀	32 μg/L Compound: CAS	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay	[PMID: 33335669]

In Vivo

Caspofungin (1-8 mg/kg; i.p.; daily, for 7 days) is able to penetrate the CNS in mice and achieve concentrations that result in the reduction of Candida burden in the brain^[1].
Caspofungin (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Complement component 5-deficient DBA/2N mice^[1]
Dosage:	1, 2, 4 and 8 mg/kg
Administration:	Intraperitoneal injection; daily, for 7 days.
Result:	Reduced the concentration of Candida load in the brain.

Animal Model:	Male C57BL/6 mice^[2]
Dosage:	0.41, 1.2, 2.5, 4.1, and 41 μM
Administration:	Intraperitoneal injection; for 5 weeks
Result:	Had nonsignificant alterations in their ERG waveforms from 0.41 to 4.1 μM.

분자량

1093.31

화학식

C₅₂H₈₈N₁₀O₁₅

CAS No.

162808-62-0

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)[C@H](C(C=C3)=CC=C3O)O)=O)([H])[C@H](O)CCN)N(CC[C@@H]4O)[C@]4([H])C(N[C@@H]([C@@H](C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)O)NCCN)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

순도&문서

Purity: 99.50%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (259 KB) HNMR (266 KB) RP-HPLC (277 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Flattery AM, et, al. Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. Antimicrob Agents Chemother. 2011 Jul;55(7):3491-7. [Content Brief]

[2]. Mojumder DK, et, al. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5796-803. [Content Brief]

Caspofungin Related Classifications

몰농도 계산기
농도 희석 계산기

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Caspofungin162808-62-0MK-0991 L-743872MK0991MK 0991L743872L 743872L-743872AntibioticFungalBacterialantifungalfungal cell wallβ-(l,3)-D-glucanInhibitorinhibitorinhibit

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Caspofungin (Synonyms: MK-0991; L-743872)

고객리뷰

Other Forms of Caspofungin:

Caspofungin Related Antibodies

10 Publications Citing Use of MCE Caspofungin

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Antibiotic Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

Caspofungin Related Classifications

몰농도 계산기

농도 희석 계산기

The molarity calculator equation

The dilution calculator equation

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