creatine-kinase

By Targets:	Amino acid Transporter (1) Angiotensin-converting Enzyme (ACE) (1) ATP Synthase (3) Biochemical Assay Reagents (3) Creatine Kinase (6) Endogenous Metabolite (12) Environmental Pollutants (1) Histone Demethylase (4) Isotope-Labeled Compounds (4) Mitochondrial Metabolism (4) P-glycoprotein (1) Reference Standards (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (6) Inflammation/Immunology (3) Metabolic Disease (11) Neurological Disease (4)

Cat. No.	Nom du produit	Target	Áreas de investigación	Chemical Structure

HY-W021448

Glycocyamine 1 Publications Verification Guanidinoacetic acid	Endogenous Metabolite	Metabolic Disease
Glycocyamine (Guanidinoacetic acid) is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming .

HY-W017540

Cyclocreatine 1 Publications Verification	ATP Synthase	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .

HY-W015114

L-2-Hydroxyglutaric acid disodium (S)-2-Hydroxyglutaric acid disodium	Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Cancer
L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-D1005A25

Poloxamer 403 (P123) PEG-PPG-PEG, 5750 (Average)	Environmental Pollutants Biochemical Assay Reagents P-glycoprotein Creatine Kinase	Neurological Disease
Poloxamer 403 P123 is a block copolymer of polyoxyethylene and polyoxypropylene with an average molecular weight of 5750. Poloxamer has the ability to inhibit P-gp. Poloxamer 403 increases *creatine kinase* levels. Poloxamer 403 is myotoxic .

HY-113039

L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Cancer
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-P2799A

Creatine Kinase (CPK/CK), Bovine Heart 1 Publications Verification CK, CPK, creatine Phosphokinase	Endogenous Metabolite Creatine Kinase	Cardiovascular Disease
Creatine Kinase (CPK/CK), Bovine Heart (CK) is a creatine kinase derived from bovine heart. Creatine Kinase (CPK/CK), Bovine Heart catalyzes the reversible phosphate transfer reaction between phosphocreatine and ADP, and is widely used in myocardial energy metabolism research and quality control of clinical biochemical tests .

HY-D0885A

*Sodium creatine* phosphate dibasic tetrahydrate** 3 Publications Verification creatine phosphate disodium tetrahydrate; creatinephosphoric acid disodium tetrahydrate	Endogenous Metabolite	Metabolic Disease
Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

HY-P2799D

Creatine Kinase MB (rCK-MB), Recombinant Human 1 Publications Verification CK-MB	Biochemical Assay Reagents	Others
Creatine Kinase MB (rCK-MB), Recombinant Human (CK-MB) is a biological material or organic compound that can be used in life science research .

HY-W015114R

L-2-Hydroxyglutaric acid disodium (Standard) (S)-2-Hydroxyglutaric acid disodium (Standard)	Reference Standards Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Cancer
L-2-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of L-2-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-W021448S1

Glycocyamine-15N,13C2 Guanidinoacetic acid-¹⁵N,¹³C₂	Endogenous Metabolite	Metabolic Disease
Glycocyamine- ¹⁵N, ¹³C₂ (Guanidinoacetic acid- ¹⁵N, ¹³C₂) is the ¹³C and ¹⁵N labeled Glycocyamine (HY-W021448) . Clycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

HY-W021448S

Glycocyamine-d2 Guanidinoacetic acid-d₂	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Glycocyamine-d₂ (Guanidinoacetic acid-d₂) is the deuterium labeled Glycocyamine (HY-W021448). Glycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

HY-P2799B

Creatine Kinase (CK/CPK), Porcine Heart CPK, CK, creatine Phosphokinase	Biochemical Assay Reagents	Others
Creatine Kinase (CK/CPK), Porcine Heart (CPK, CK, Creatine Phosphokinase) is a biological material or organic compound that can be used in life science research .

HY-P2799C

Creatine Kinase BB (CK-BB) Isoenzyme, Porcine Brain CPK-1, CKBB isoenyzme, CK-BB	Endogenous Metabolite	Others
Creatine Kinase BB (CK-BB) Isoenzyme, Porcine Brain (CPK-1, CKBB isoenyzme, CK-BB) is a biological material or organic compound that can be used in life science research .

HY-P2799I

Creatine Kinase BB (CK-BB), human brain	Creatine Kinase	Inflammation/Immunology
Creatine Kinase BB (CK-BB), human brain is a specific isoenzyme of creatine kinase (E.C. 2.7.3.2) primarily derived from human brain tissue. Creatine Kinase BB can be used for the study of radioimmunoassay techniques .

HY-125863A

Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) G6PD (Leuconostoc sp., recombinant)	Endogenous Metabolite	Metabolic Disease
Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) is an NADP-dependent enzyme in the pentose phosphate pathway, which is one of the ways glucose is metabolized. Glucose-6-phosphate dehydrogenase (Leuconostoc sp., recombinant) can be used to quantify ATP, glucose, and creatine kinase .

HY-A0113

Cilazaprilat Ro 31-3113	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Cilazaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC₅₀=0.7 nM for the rat enzyme) and an active metabolite of Cilazapril (HY-A0043). It decreases creatine kinase release in primary neonatal rat cardiac myocytes in an in vitro model of ischemia-reperfusion injury induced by hypoxia and reoxygenation when used at a concentration of 10 μM.3 Intra-arterial administration of cilazaprilat (3 μg/kg per minute) increases coronary blood flow and fractional shortening in a dog model of coronary hypoperfusion-induced myocardial ischemia.

HY-W017540R

Cyclocreatine (Standard)	Reference Standards ATP Synthase	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .

HY-E70969

Creatine Kinase, Porcine	Creatine Kinase	Metabolic Disease
Creatine Kinase, Porcine (EC 2.7.3.2) is an enzyme present in muscle, brain, and other tissues of vertebrates that catalyzes the reversible conversion of ADP and phosphocreatine into ATP and creatine.

HY-W744986

L-2-Hydroxyglutaric acid-d5 disodium (2S)-2-Hydroxyglutaric acid-d5 disodium	Isotope-Labeled Compounds Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite	Cancer
L-2-Hydroxyglutaric acid-d₅ disodium ((2S)-2-Hydroxyglutaric acid-d₅ disodium) is the deuterium labeled L-2-Hydroxyglutaric acid disodium (HY-W015114). L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively .

HY-W754199

Glycocyamine-13C Guanidinoacetic acid-¹³C	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Glycocyamine- ¹³C (Guanidinoacetic acid- ¹³C) is the ¹³C-labeled Glycocyamine (HY-W021448). Glycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

HY-W017540S

Cyclocreatine-13C3	Isotope-Labeled Compounds ATP Synthase	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Cyclocreatine- ¹³C₃ is the ¹³C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .

HY-181753

INSP-0154	Creatine Kinase Amino acid Transporter	Inflammation/Immunology Cancer
INSP-0154 is a potent creatine kinase B (CKB)/creatine transporter (SLC6A8) inhibitor. INSP-0154 binds to the SLC6A8 occluded pocket, prevents creatine transport into cells, and protects SLC6A8 cysteine residue C144 from irreversible inactivation. INSP-0154 inhibits creatine uptake in mouse heart tissue. INSP-0154 can be used for the research of cancer .

HY-148150A

Cyclocreatine phosphate dilithium	Creatine Kinase	Cardiovascular Disease Inflammation/Immunology Cancer
Cyclocreatine phosphate dilithium is a synthetic intracellular energy buffer. Cyclocreatine phosphate dilithium mediates antiproliferative activity in cells with high creatine kinase levels and inhibits solid tumor growth. Cyclocreatine phosphate dilithium maintains adenosine triphosphate (ATP) levels and protects tissues from hypoxia, cellular damage and inflammation during ischemic events. Cyclocreatine phosphate dilithium accumulates in skeletal muscle, reduces muscle phosphocreatine and total creatine levels, and acts both as a bioenergetic/anti-inflammatory agent and an experimental tool for the assessment of ischemic injury. Cyclocreatine phosphate dilithium can be used in studies related to solid tumors, heart failure and ischemia .

Cat. No.	Nom du produit	Type

HY-D1005A25

Poloxamer 403 (P123) PEG-PPG-PEG, 5750 (Average)	Biochemical Assay Reagents
Poloxamer 403 P123 is a block copolymer of polyoxyethylene and polyoxypropylene with an average molecular weight of 5750. Poloxamer has the ability to inhibit P-gp. Poloxamer 403 increases *creatine kinase* levels. Poloxamer 403 is myotoxic .

Cat. No.	Nom du produit	Target	Research Area

HY-P4698

Tri-valine NSC 35938	Peptides	Metabolic Disease
Tri-valine (NSC 35938) is a polypeptide that can be separated from Creatine kinase (HY-P2799), β-enolase, Triosephosphate isomerase (HY-P2931) and glyceraldehyde 3-phosphate dehydrogenase .

Cat. No.	Nom du produit	Category	Target	Chemical Structure

HY-W021448

Glycocyamine 1 Publications Verification Guanidinoacetic acid	Structural Classification Other disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Glycocyamine (Guanidinoacetic acid) is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming .

HY-W015114

L-2-Hydroxyglutaric acid disodium (S)-2-Hydroxyglutaric acid disodium	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-113039

L-2-Hydroxyglutaric acid (S)-2-Hydroxyglutaric acid	Microorganisms Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer Source Classification	Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

HY-D0885A

*Sodium creatine* phosphate dibasic tetrahydrate** 3 Publications Verification creatine phosphate disodium tetrahydrate; creatinephosphoric acid disodium tetrahydrate	Structural Classification Classification of Application Fields Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Phosphocreatine disodium tetrahydrate, primarily found in the skeletal muscles of vertebrates and one of organic compounds known as alpha amino acids and derivatives, is a substrate for the determination of creatine kinase and used to regenerate ATP during skeletal muscle contraction .

HY-W015114R

L-2-Hydroxyglutaric acid disodium (Standard) (S)-2-Hydroxyglutaric acid disodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
L-2-Hydroxyglutaric acid (disodium) (Standard) is the analytical standard of L-2-Hydroxyglutaric acid (disodium). This product is intended for research and analytical applications. L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with K_m and K_i of 2.52 mM and 11.13 mM, respectively .

Species:	Human (4) Rat (2) Mouse (1)
Tag:	His (6)
Source:	HEK293 (1) Sf9 insect cells (1) E. coli (5)

Cat. No.	Compare	Nom du produit	Species	Source	Image

HY-P76827

	CKMT2 Protein, Rat (His) creatine kinase; Basic-type mitochondrial creatine kinase; Mib-CK; S-MtCK	Rat	E. coli
	CKMT2 Protein is a member of the ATP:guanido phosphotransferase family. CKMT2 Protein, Rat (His) is the recombinant rat-derived CKMT2 protein, expressed by E. coli , with N-His labeled tag.

HY-P700577

	Creatine kinase M-type/CKM Protein, Mouse (His) rHucreatine kinase M-type/CKMM, His; creatine kinase M-type; creatine kinase M chain; M-CK; CKM; CKMM	Mouse	E. coli
	CKM is a creatine kinase M-type protein that centrally catalyzes reversible phosphate transfer between ATP and various phosphogens, especially creatine phosphate. As a creatine kinase isoenzyme, CKM plays a crucial role in energy transduction, particularly in tissues with large and fluctuating energy demands, such as skeletal muscle, heart, brain, and sperm. Creatine kinase M-type/CKM Protein, Mouse (His) is the recombinant mouse-derived Creatine kinase M-type/CKM protein, expressed by E. coli , with N-6*His labeled tag.

HY-P76827A

	CKMT2 Protein, Rat (His, Solution) creatine kinase; Basic-type mitochondrial creatine kinase; Mib-CK; S-MtCK	Rat	E. coli
	The CKMT2 protein is predicted to have ubiquitin protein transferase activity and participate in the regulation of the epidermal growth factor receptor signaling pathway. It is involved in autoubiquitination and ubiquitin-dependent protein catabolic processes through the multivesicular body sorting pathway. CKMT2 Protein, Rat (His, Solution) is the recombinant rat-derived CKMT2 protein, expressed by E. coli , with N-His labeled tag.

HY-P7827

	Creatine kinase M-type/CKM Protein, Human (HEK293, His) rHucreatine kinase M-type/CKMM, His; creatine kinase M-type; creatine kinase M chain; M-CK; CKM; CKMM	Human	HEK293
	KCRM is a cytoplasmic creatine kinase isoenzyme responsible for participating in energy transduction and maintaining energy homeostasis. KCRM reversibly catalyzes phosphate transfer between ATP and various phosphogens (e.g., creatine phosphate) and is an important serum marker of myocardial infarction. Creatine kinase M-type/CKM Protein, Human (HEK293, His) is the recombinant human-derived Creatine kinase M-type/CKM protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7897

	Creatine kinase B-type/CKB Protein, Human (His) rHucreatine kinase B-type/CKB , His; B-CK; CKB; creatine kinase BB	Human	E. coli
	Creatine kinaseB-type/CKB Protein, Human (His) is the most abundant creatine kinase isoenzyme in purified brown adipocytes. CKB reversibly catalyzes the transfer of phosphate between ATP and various phosphogens.

HY-P75340

	Creatine kinase M-type/CKM Protein, Human (His) CKM; CKMM; CKMMcreatine kinase M-type; M-CK	Human	E. coli
	Creatine kinase M-type/CKM Protein, Human (His) is the recombinant human-derived Creatine kinase M-type/CKM protein, expressed by E. coli, with N-His labeled tag.

HY-P76264

	CKMT1A Protein, Human (sf9, His) creatine kinase U-type, mitochondrial; Mia-CK; U-MtCK; CKMT; CKMT1B	Human	Sf9 insect cells
	CKMT1A is a creatine kinase isoenzyme that plays a key role in the reversible transfer of phosphate between ATP and creatine phosphate. The function of this enzyme is critical for tissues with dynamic energy needs, such as skeletal muscle, heart, brain, and sperm. CKMT1A Protein, Human (sf9, His) is the recombinant human-derived CKMT1A protein, expressed by Sf9 insect cells , with N-His labeled tag.

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Cat. No.	Nom du produit	Chemical Structure

HY-W021448S1

Glycocyamine-15N,13C2
Glycocyamine- ¹⁵N, ¹³C₂ (Guanidinoacetic acid- ¹⁵N, ¹³C₂) is the ¹³C and ¹⁵N labeled Glycocyamine (HY-W021448) . Clycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

Glycocyamine-15N,13C2

Glycocyamine- ¹⁵N, ¹³C₂ (Guanidinoacetic acid- ¹⁵N, ¹³C₂) is the ¹³C and ¹⁵N labeled Glycocyamine (HY-W021448) . Clycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

HY-W021448S

Glycocyamine-d2
Glycocyamine-d₂ (Guanidinoacetic acid-d₂) is the deuterium labeled Glycocyamine (HY-W021448). Glycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

Glycocyamine-d2

Glycocyamine-d₂ (Guanidinoacetic acid-d₂) is the deuterium labeled Glycocyamine (HY-W021448). Glycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

HY-W744986

L-2-Hydroxyglutaric acid-d5 disodium

L-2-Hydroxyglutaric acid-d₅ disodium ((2S)-2-Hydroxyglutaric acid-d₅ disodium) is the deuterium labeled L-2-Hydroxyglutaric acid disodium (HY-W015114). L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation . L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively .

HY-W754199

Glycocyamine-13C

Glycocyamine- ¹³C (Guanidinoacetic acid- ¹³C) is the ¹³C-labeled Glycocyamine (HY-W021448). Glycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming.

HY-W017540S

Cyclocreatine-13C3

Cyclocreatine- ¹³C₃ is the ¹³C-labeled Cyclocreatine (HY-W017540). Cyclocreatine, a creatine analogue, acts as a brain-penetrant and potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine can be phosphorylated and dephosphorylated by creatine kinases. Cyclocreatine suppresses creatine metabolism ameliorating the cognitive, autistic and epileptic phenotype in a mouse model of creatine transporter defciency. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion in dogs and rats. Cyclocreatine decreases plaque-adjacent neuronal dystrophy in TREM2-deficient mice with amyloid-β pathology. Cyclocreatine is proming for research of ischemic heart disease, cardiovascular diseases, Alzheimer’s disease and other neurodegenerative diseases associated with microglial dysfunction, prostate cancer .

Host:	Mouse (6) Rabbit (3)
Reactivity:	Human (8) Rat (6) Mouse (5)
Application:	IHC-P (4) ICC/IF (3) IF-Tissue (2) IP (2) WB (6) ELISA (5)
Isotype:	IgG (5) IgG2b (2)
Conjugation:	Non-conjugated (9)
Clonality:	Monoclonal (6) Recombinant (1)
Modification:	Unmodified (6)

Cat. No.	Compare	Nom du produit	Application	Reactivity	Image

HY-P85625

	Creatine Kinase MM Antibody (YA5317) CKM; CKMM; creatine kinase M; creatine kinase M chain; creatine kinase M type; creatine kinase M-type; creatine kinase muscle; creatine kinase, muscle type; KCRM_HUMAN; M-CK; MCK; Muscle creatine kinase.	ELISA	Human
	Creatine Kinase MM Antibody (YA5317) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Creatine Kinase MM.

HY-P81316

	Creatine Kinase MM Antibody (YA1061) CKM; CKMM; creatine kinase M-type; creatine kinase M chain; M-CK	ELISA	Human
	Creatine Kinase MM Antibody (YA1061) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Creatine Kinase MM.

HY-P81316A

	Creatine Kinase MM Antibody (YA1061)(PBS only) CKM; CKMM; creatine kinase M-type; creatine kinase M chain; M-CK	ELISA	Human
	Creatine Kinase MM Antibody (YA1061) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Creatine Kinase MM.

HY-P85468

	CKMT2 Antibody (YA5160) CKMT2; creatine kinase S-type; mitochondrial; Basic-type mitochondrial creatine kinase; Mib-CK; Sarcomeric mitochondrial creatine kinase; S-MtCK	WB, IHC-P, ICC/IF, IP, ELISA, IF-Tissue	Human, Mouse, Rat
	CKMT2 Antibody (YA5160) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CKMT2.

HY-P85560

	CKMT2 Antibody (YA5252) CKMT 2; Basic-type mitochondrial creatine kinase; CKMT 2; CKMT2; CPK; creatine kinase mitochondrial 2; creatine kinase mitochondrial 2; sarcomeric; creatine kinase S-type; creatine kinase S-type, mitochondrial; KCRS_HUMAN; Mib CK; Mib-CK; mitochondrial; OTTHUMP00000147542; S-MtCK; Sarcomeric mitochondrial creatine kinase; SMTCK.	WB	Rat
	CKMT2 Antibody (YA5252) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CKMT2.

HY-P811018

	CKMT2 Antibody Basic-type mitochondrial creatine kinase, Sarcomeric mitochondrial creatine kinase, Mib-CK, S-MtCK, CKMT2	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	CKMT2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to CKMT2.

HY-P85480

	CKMT1 Antibody (YA5172) CKMT1A; CKMT; CKMT1B; CKMT; creatine kinase U-type; mitochondrial; Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK	WB, ICC/IF, IP, ELISA, IF-Tissue	Human, Mouse, Rat
	CKMT1 Antibody (YA5172) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CKMT1.

HY-P80629

	Creatine Kinase B type Antibody (YA492) BCK; Ckb; CKBB; HEL 211; HEL S 29	WB, IHC-P	Human, Mouse, Rat
	Creatine Kinase B type Antibody (YA492) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Creatine Kinase B type.

HY-P80629A

	Creatine Kinase B type Antibody (YA492)(PBS only) BCK; Ckb; CKBB; HEL 211; HEL S 29	WB, IHC-P	Human, Mouse, Rat
	Creatine Kinase B type Antibody (YA492) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Creatine Kinase B type.

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