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Cyclocreatine is a Creatine analogue and acts as a potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine crosses membranes, enters the brain, and can be phosphorylated and dephosphorylated by creatine kinases.

For research use only. We do not sell to patients.

Cyclocreatine Chemical Structure

Cyclocreatine Chemical Structure

CAS No. : 35404-50-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in Water
ready for reconstitution
USD 55 In-stock
Solution
10 mM * 1 mL in Water USD 55 In-stock
Solid
100 mg USD 50 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Cyclocreatine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cyclocreatine is a Creatine analogue and acts as a potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine crosses membranes, enters the brain, and can be phosphorylated and dephosphorylated by creatine kinases[1].

Molecular Weight

143.15

Formula

C5H9N3O2

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(O)CN1CCNC1=N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

1M HCl : 100 mg/mL (698.57 mM; ultrasonic and adjust pH to 2 with HCl)

H2O : 5 mg/mL (34.93 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.9857 mL 34.9284 mL 69.8568 mL
5 mM 1.3971 mL 6.9857 mL 13.9714 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (69.86 mM); Clear solution; Need ultrasonic and warming

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.65%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 1M HCl 1 mM 6.9857 mL 34.9284 mL 69.8568 mL 174.6420 mL
5 mM 1.3971 mL 6.9857 mL 13.9714 mL 34.9284 mL
10 mM 0.6986 mL 3.4928 mL 6.9857 mL 17.4642 mL
15 mM 0.4657 mL 2.3286 mL 4.6571 mL 11.6428 mL
20 mM 0.3493 mL 1.7464 mL 3.4928 mL 8.7321 mL
25 mM 0.2794 mL 1.3971 mL 2.7943 mL 6.9857 mL
30 mM 0.2329 mL 1.1643 mL 2.3286 mL 5.8214 mL
1M HCl 40 mM 0.1746 mL 0.8732 mL 1.7464 mL 4.3660 mL
50 mM 0.1397 mL 0.6986 mL 1.3971 mL 3.4928 mL
60 mM 0.1164 mL 0.5821 mL 1.1643 mL 2.9107 mL
80 mM 0.0873 mL 0.4366 mL 0.8732 mL 2.1830 mL
100 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.7464 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclocreatine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cyclocreatine
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