L-2-Hydroxyglutaric acid
Based on 1 Customer Validation
L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 95.11%
- No. CAS: 13095-48-2
- Fòrmula: C5H8O5
- Peso molecular:148.11
-
Almacenamiento:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-12304
IOX12OG Oxygenases Inhibitor -
HY-12725
ML324JMJD2 Inhibitor -
HY-15648B
GSK-J4JMJD3/UTX Inhibitor -
HY-101799
NCGC00244536KDM4B Inhibitor -
HY-109169A
Bomedemstat ditosylateLSD1 Inhibitor -
HY-13953
JIB-04Histone Demethylase Inhibitor -
HY-15648
GSK-J1JMJD3/KDM6B Inhibitor -
HY-12635
SP2509LSD1 Antagonist -
HY-139348
PFI-90KDM3B Inhibitor -
HY-15221
MethylstatHistone Demethylases Inhibitor -
HY-101799R
NCGC00244536 (Standard)Reference Standard -
HY-128343
KDM4-IN-2Histone Demethylase Inhibitor
Ver todos los productos específicos de isoformas Endogenous Metabolite
More
Actividad biológica
Descripciòn
IC50 & Target
|
Human Endogenous Metabolite |
In Vitro
Chemical Information
-
No. CAS 13095-48-2
-
Appearance Liquid
-
Peso molecular 148.11
-
Fòrmula C5H8O5
-
Color Colorless to light yellow
-
SMILES
O=C(O)[C@@H](O)CCC(O)=O
-
Synonyms
(S)-2-Hydroxyglutaric acid
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Solution, -20°C, 2 years
Pureza y Documentación
-
Ficha de datos (266 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8. [Content Brief]
[2]. da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-2-Hydroxyglutaric acid Related Classifications
HY-113039 Related Classifications
Powered by Bioz