2. Epigenetics Metabolic Enzyme/Protease
  3. Histone Demethylase Mitochondrial Metabolism Endogenous Metabolite
  4. L-2-Hydroxyglutaric acid

L-2-Hydroxyglutaric acid  (Synonyms: (S)-2-Hydroxyglutaric acid)

Cat. No.: HY-113039
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L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.

For research use only. We do not sell to patients.

L-2-Hydroxyglutaric acid Chemical Structure

L-2-Hydroxyglutaric acid Chemical Structure

CAS No. : 13095-48-2

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Based on 1 publication(s) in Google Scholar

Other Forms of L-2-Hydroxyglutaric acid:

L-2-Hydroxyglutaric acid Related Antibodies

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Description

L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-2-Hydroxyglutaric acid Related Antibodies
Molecular Weight

148.11

Formula

C5H8O5
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)[C@@H](O)CCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Solution, -20°C, 2 years
Purity & Documentation

Purity: ≥95.0%

COA (244 KB)

Handling Instructions (2659 KB)
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L-2-Hydroxyglutaric acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-2-Hydroxyglutaric acid13095-48-2(S)-2-Hydroxyglutaric acidHistone DemethylaseMitochondrial MetabolismEndogenous MetaboliteepigeneticmodifierrenalcancerhistonedemethylasesmethylationInhibitorinhibitorinhibit

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