1. Epigenetics
    Metabolic Enzyme/Protease
  2. Histone Demethylase
    Mitochondrial Metabolism
    Endogenous Metabolite
  3. L-2-Hydroxyglutaric acid

L-2-Hydroxyglutaric acid (Synonyms: (S)-2-Hydroxyglutaric acid)

Cat. No.: HY-113039
Handling Instructions

L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.

For research use only. We do not sell to patients.

L-2-Hydroxyglutaric acid Chemical Structure

L-2-Hydroxyglutaric acid Chemical Structure

CAS No. : 13095-48-2

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Description

L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].

Molecular Weight

148.11

Formula

C₅H₈O₅

CAS No.

13095-48-2

SMILES

O=C(O)[[email protected]@H](O)CCC(O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

L-2-Hydroxyglutaric acid(S)-2-Hydroxyglutaric acidHistone DemethylaseMitochondrial MetabolismEndogenous MetaboliteepigeneticmodifierrenalcancerhistonedemethylasesmethylationInhibitorinhibitorinhibit

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L-2-Hydroxyglutaric acid
Cat. No.:
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