13095-48-2
13095-48-2
Chemical Structure
L-2-Hydroxyglutaric acid
Synonym(s): (S)-2-Hydroxyglutaric acid
- CAS No.: 13095-48-2
- Formula:C5H8O5
- Molecular Weight:148.11
IUPAC Name: (S)-2-hydroxypentanedioic acid
InChIKey: HWXBTNAVRSUOJR-VKHMYHEASA-N
SMILES: O=C(O)[C@@H](O)CCC(O)=O
Biological Activity: L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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L-2-Hydroxyglutaric acid | 95.11% | L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively. | ||||||||||||||||||||
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References
- [1]. Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8. [Content Brief]
- [2]. da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24. [Content Brief]
Keywords
