1. Epigenetics
    Metabolic Enzyme/Protease
  2. Histone Demethylase
    Mitochondrial Metabolism
  3. L-2-Hydroxyglutaric acid disodium

L-2-Hydroxyglutaric acid disodium (Synonyms: (S)-2-Hydroxyglutaric acid disodium)

Cat. No.: HY-W015114 Purity: >95.0%
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L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively.

For research use only. We do not sell to patients.

L-2-Hydroxyglutaric acid disodium Chemical Structure

L-2-Hydroxyglutaric acid disodium Chemical Structure

CAS No. : 63512-50-5

Size Price Stock Quantity
10 mM * 1 mL in Water USD 61 In-stock
Estimated Time of Arrival: December 31
10 mg USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 165 In-stock
Estimated Time of Arrival: December 31
100 mg USD 225 Get quote
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Based on 1 publication(s) in Google Scholar

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Description

L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

In Vitro

L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].

Molecular Weight

192.08

Formula

C₅H₆Na₂O₅

CAS No.

63512-50-5

SMILES

O=C(O[Na])[[email protected]@H](O)CCC(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (433.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2062 mL 26.0308 mL 52.0616 mL
5 mM 1.0412 mL 5.2062 mL 10.4123 mL
10 mM 0.5206 mL 2.6031 mL 5.2062 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >95.0%

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Keywords:

L-2-Hydroxyglutaric acid disodium(S)-2-Hydroxyglutaric acid disodiumHistone DemethylaseMitochondrial MetabolismepigeneticmodifierrenalcancerhistonedemethylasesmethylationInhibitorinhibitorinhibit

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Product Name:
L-2-Hydroxyglutaric acid disodium
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HY-W015114
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