1. Apoptosis
  2. Apoptosis
    Bcl-2 Family
  3. Dihydrokaempferol

Dihydrokaempferol 

Cat. No.: HY-N2897
Handling Instructions

Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs.

For research use only. We do not sell to patients.

Dihydrokaempferol Chemical Structure

Dihydrokaempferol Chemical Structure

CAS No. : 480-20-6

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Description

Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1].

IC50 & Target

Apoptosis; Bcl-2; Bcl-xL[1]

In Vitro

Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs[1].
Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively)[1].
Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP[1].

Cell Proliferation Assay[1]

Cell Line: Normal synoviocyte cells; RA-FLS cells
Concentration: 0.3 μM, 3 μM, 30 μM, 300 μM
Incubation Time: 48 hours
Result: Decreased the proliferation of RA-FLSs.

Apoptosis Analysis[1]

Cell Line: RA-FLS cells
Concentration: 3 μM, 30 μM
Incubation Time: 48 hours
Result: Induced apoptosis in RA-FLSs.

Western Blot Analysis[1]

Cell Line: RA-FLS cells
Concentration: 3 μM, 30 μM
Incubation Time: 48 hours
Result: Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression.
Molecular Weight

288.25

Formula

C₁₅H₁₂O₆

CAS No.

480-20-6

SMILES

O=C1C2=C(O)C=C(O)C=C2O[[email protected]](C3=CC=C(O)C=C3)[[email protected]]1O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Dihydrokaempferol
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HY-N2897
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