DSPE-PEG2000-cRGD

製品番号: HY-172464 純度: 96.23%: Data Sheet SDS COA 取扱説明書
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DSPE-PEG2000-cRGD is a PEG compound which composed of DSPE and an αvβ3 targeting peptide (cRGD). cRGD peptide can specifically bind to αvβ3 on the surface of many cancer cells and neovascular cells. DSPE-PEG2000-cRGD can be used for drug delivery.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

DSPE-PEG2000-cRGD 構造式

容量	価格（税別）	在庫状況
10 mg	$850	見積もりとリードタイムを求めるのご確認
25 mg	$1675	見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Integrin アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

生物活性
純度とドキュメンテーション
参考文献
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製品説明

IC₅₀ & Target^[1]

αvβ3

体外実験

DSPE-PEG2000-cRGD can be used to construct pp-siRNA/CLD/DNCA/DSPE-PEG2000-cRGD (PCNR). pp-siRNA/CLD/DNCA/DSPE-PEG2000-cRGD nanoparticles can specifically target tumor cells that highly express integrin αvβ3^[2].
Incorporating DSPE-PEG2000-cRGD into liposomes can form spatially stable and integrin-targeting liposomes^[3].
DSPE-PEG2000-cRGD can be used to construct C-siRNA/MTSLR-U and C-siRNA/MTSLR, which have anti-hepatocellular carcinoma activity^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2000 (Average)

Appearance

Solid

Color

White to off-white

SMILES

[Cyclo(RGD-{d-Phe}-K)]C(CCOCCOC(NCCOP(OC[C@](COC(CCCCCCCCCCCCCCCCC)=O)([H])OC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O.[n]

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

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濃度 _（終了）

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 96.23%

Select Batch:

データシート (271 KB) SDS (252 KB)

COA (246 KB) HNMR (185 KB) RP-HPLC (253 KB) MS (160 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Gajbhiye KR, et al. cRGD functionalised nanocarriers for targeted delivery of bioactives. J Drug Target. 2019 Feb;27(2):111-124. [Content Brief]

[2]. Zhang Y, et al. Construction of a Targeting Nanoparticle of 3',3″-Bis-Peptide-siRNA Conjugate/Mixed Lipid with Postinserted DSPE-PEG2000-cRGD. Mol Pharm. 2019 Dec 2;16(12):4920-4928. [Content Brief]

[3]. Khabazian E, et al. Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells. J Drug Target. 2022 Jun;30(5):522-533. [Content Brief]

[4]. Nai J, et al. Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells. Mol Ther Nucleic Acids. 2021 Dec 11;27:349-362. [Content Brief]