2. Anti-infection
  3. Parasite
  4. Eflornithine

Eflornithine  (Synonyms: DFMO; MDL71782; RMI71782; α-difluoromethylornithine)

製品番号: HY-B0744 純度: 99.87%
COA 取扱説明書 Technical Support

Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 70052-12-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in Water USD 55 在庫あり
Solid
100 mg $50 在庫あり
500 mg $150 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 21 publication(s) in Google Scholar

Other Forms of Eflornithine:

Eflornithine 関連抗体

Top Publications Citing Use of Products

    Eflornithine purchased from MedChemExpress. Usage Cited in: Immunity. 2025 Aug 12;58(8):2019-2034.e11.  [Abstract]

    Csnk2bTreg−/− and Csnk2bfl/fl mice were inoculated with B16.F10 cells and then orally administered Eflornithine hydrochloride hydrate (1% w/v) in combination with subcutaneous injection of AMXT 1501 around the tumor. We measured tumor growth and analyzed the phenotype of Treg cells in the tumor microenvironment (TME) using multicolor flow cytometry. The combination therapy had no effect on tumor growth in Csnk2bTreg−/− mice but significantly inhibited tumor growth in Csnk2bfl/fl mice.

    Eflornithine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e12508.  [Abstract]

    Bar graphs showing the proportion of ALDH+ cells in OVCAR3, OVCAR8, and SKOV3 treated with THP-1-derived Mφ+ACs CM, THP-1-derived Mφ+ACs treated with 1 mM Eflornithine CM, respectively, for 48 h were presented.

    Eflornithine purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 21:e12508.  [Abstract]

    Bar graph showing the relative mRNA expression of SOX2, ALDH1A1, and ALDH1A3 in OVCAR3 treated with THP-1 derived Mφ +ACs CM, THP-1 derived Mφ+ACs treated with 1 mM Eflornithine CM separately for 48 h.

    Eflornithine purchased from MedChemExpress. Usage Cited in: Sci Adv. 2023 May 19;9(20):eade0718.  [Abstract]

    Percentage of IFN-γ+ and mean fluorescence intensity (MFI) of Ki-67 in CD8+ T cells after anti-CD3 antibody stimulation versus anti-CD3 antibody plus rSema4A stimulation with or without Sardomozide Dihydrochloride (10 μM) and Eflornithine hydrochloride hydrate (500 μM).

    Eflornithine purchased from MedChemExpress. Usage Cited in: Commun Biol. 2019 May 8:2:171.  [Abstract]

    Eflornithine (DFMO) was administered as a 1% solution in drinking distilled H₂O to mice for 14 days. The mean DFMO consumption of mice was ∼1.5 g/kg/d. Immunostaining of IDO1 in the ileum after L-Orn administration in wt mice or after L-Orn inhibitor DFMO administration in human REG3Atg mice was performed.

    Eflornithine purchased from MedChemExpress. Usage Cited in: Commun Biol. 2019 May 8:2:171.  [Abstract]

    Eflornithine (DFMO) was administered as a 1% solution in drinking distilled H₂O to mice for 14 days. The mean DFMO consumption of mice was ∼1.5 g/kg/d. HPLC/MASS of L-Kyn in the ileum epithelial cells after administration of L-Orn or L-Orn inhibitor DFMO.

    Eflornithine purchased from MedChemExpress. Usage Cited in: Commun Biol. 2019 May 8:2:171.  [Abstract]

    Eflornithine (DFMO) was administered as a 1% solution in drinking distilled H₂O to mice for 14 days. The mean DFMO consumption of mice was ∼1.5 g/kg/d. Flow cytometry of RORγt (+) IL-22(+) cells in the ileum of mice after administering L-Orn or L-Orn inhibitor DFMO.

    Parasite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    • 生物活性

    • プロトコル

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

    IC50 & Target

    Trypanosoma

     

    Cellular Effect
    Cell Line Type Value Description References
    HEK293 EC50
    >100 μM
    Compound: Eflornithine
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay
    Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by alamar blue assay
    		[PMID: 27720295]
    HepG2 CC50
    >100 μM
    Compound: Eflornithine
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
    		[PMID: 32292551]
    HepG2 CC50
    >100 μM
    Compound: Eflornithine
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 32652409]
    HepG2 CC50
    >100 μM
    Compound: Eflornithine
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
    		[PMID: 32795774]
    L6 IC50
    12 μg/mL
    Compound: Eflornithine
    Cytotoxicity against in rat L6 cells assessed as reduction in cell viability after 70 hrs by alamar blue assay
    Cytotoxicity against in rat L6 cells assessed as reduction in cell viability after 70 hrs by alamar blue assay
    		[PMID: 21353728]
    MRC5 IC50
    >100 μg/mL
    Compound: eflornithine
    Cytotoxicity against human MRC5 cells after 7 days by MTT assay
    Cytotoxicity against human MRC5 cells after 7 days by MTT assay
    		[PMID: 19013823]
    MRC5 IC50
    >100 μg/mL
    Compound: Eflornithine
    Cytotoxicity against human MRC5 cells
    Cytotoxicity against human MRC5 cells
    		[PMID: 24388808]
    体内実験

    Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    182.17

    分子式

    C6H12F2N2O2
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    NC(CCCN)(C(F)F)C(O)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 83.33 mg/mL (457.43 mM; ultrasonic and warming and heat to 60°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.4894 mL 27.4469 mL 54.8938 mL
    5 mM 1.0979 mL 5.4894 mL 10.9788 mL
    10 mM 0.5489 mL 2.7447 mL 5.4894 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    体積 （開始）

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    (per animal)

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.87%

    COA (245 KB) HNMR (131 KB) RP-HPLC (237 KB) MS (71 KB)

    取扱説明書 (2659 KB)
    参考文献
    動物実験
    [3]

    Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (∼50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.4894 mL 27.4469 mL 54.8938 mL 137.2345 mL
    5 mM 1.0979 mL 5.4894 mL 10.9788 mL 27.4469 mL
    10 mM 0.5489 mL 2.7447 mL 5.4894 mL 13.7234 mL
    15 mM 0.3660 mL 1.8298 mL 3.6596 mL 9.1490 mL
    20 mM 0.2745 mL 1.3723 mL 2.7447 mL 6.8617 mL
    25 mM 0.2196 mL 1.0979 mL 2.1958 mL 5.4894 mL
    30 mM 0.1830 mL 0.9149 mL 1.8298 mL 4.5745 mL
    40 mM 0.1372 mL 0.6862 mL 1.3723 mL 3.4309 mL
    50 mM 0.1098 mL 0.5489 mL 1.0979 mL 2.7447 mL
    60 mM 0.0915 mL 0.4574 mL 0.9149 mL 2.2872 mL
    80 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7154 mL
    100 mM 0.0549 mL 0.2745 mL 0.5489 mL 1.3723 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Eflornithine Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Eflornithine70052-12-9DFMO MDL71782 RMI71782 α-difluoromethylornithineMDL71782MDL 71782MDL-71782RMI71782RMI 71782RMI-71782ParasiteInhibitorinhibitorinhibit

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    製品番号:
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