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Eflornithine hydrochloride, hydrate (Synonyms: DFMO hydrochloride hydrate; MDL-71782 hydrochloride hydrate; RMI-71782 hydrochloride hydrate; α-difluoromethylornithine hydrochloride hydrate)

Cat. No.: HY-B0744B Purity: >98.0%
Handling Instructions

Eflornithine hydrochloride, hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

For research use only. We do not sell to patients.

Eflornithine hydrochloride, hydrate Chemical Structure

Eflornithine hydrochloride, hydrate Chemical Structure

CAS No. : 96020-91-6

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10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
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Based on 2 publication(s) in Google Scholar

Other Forms of Eflornithine hydrochloride, hydrate:

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Description

Eflornithine hydrochloride, hydrate is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.

In Vivo

Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases[1]. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism[2]. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles[3]. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension[4].

Clinical Trial
Molecular Weight

236.64

Formula

C₆H₁₅ClF₂N₂O₃

CAS No.

96020-91-6

SMILES

NC(CCCN)(C(F)F)C(O)=O.[H]Cl.O

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 57 mg/mL (240.87 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2258 mL 21.1291 mL 42.2583 mL
5 mM 0.8452 mL 4.2258 mL 8.4517 mL
10 mM 0.4226 mL 2.1129 mL 4.2258 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[3]

Mice: The skin area where the hair is removed is then treated with the eflornithine hydrochloride 13.9% cream (-50 mg per mouse per treatment) using a spatula 2 times a day in an interval of at least 8 h for a maximum period of 36 days[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Eflornithine hydrochloride, hydrate
Cat. No.:
HY-B0744B
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