2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Carbonic Anhydrase Phosphodiesterase (PDE)
  4. Enpp/Carbonic anhydrase-IN-1

Enpp/Carbonic anhydrase-IN-1 

Cat. No.: HY-151916 Purity: 99.57%
COA Handling Instructions

Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis.

For research use only. We do not sell to patients.

Enpp/Carbonic anhydrase-IN-1 Chemical Structure

Enpp/Carbonic anhydrase-IN-1 Chemical Structure

CAS No. : 2883495-35-8

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Based on 1 publication(s) in Google Scholar

Enpp/Carbonic anhydrase-IN-1 Related Antibodies

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CA I CA Ⅱ CA Ⅸ CA XII

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Description

Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis[1].

IC50 & Target[1]

CA Ⅱ

0.88 μM (IC50)

CA Ⅸ

1.02 μM (IC50)

NPP1

1.36 μM (IC50)

NPP2

1.35 μM (IC50)

NPP3

3.00 μM (IC50)

In Vitro

Enpp/Carbonic anhydrase-IN-1 (compound 1e) (0-100 µM; ) inhibits some cancer cells growth with IC50s of 0.32, 0.40, 0.58, 0.87, 0.40, 0.96 µM for K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells, respectively[1].
Enpp/Carbonic anhydrase-IN-1 (0-2 µM) shows low cytotoxic against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s of > 50 μM[1].
Enpp/Carbonic anhydrase-IN-1 (0.32, 0.64 µM) induces apoptosis in a dose-dependent manner at K-562 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Enpp/Carbonic anhydrase-IN-1 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells
Concentration: 0-100 µM
Incubation Time:
Result: Inhibited the cell growth with IC50s of 0.32, 0.40, 0.58, 0.87, 0.40, 0.96 µM for K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells, respectively.

Apoptosis Analysis[1]

Cell Line: K-562 cells
Concentration: 0.32, 0.64 µM
Incubation Time:
Result: Induced apoptosis in a dose-dependent manner.
Molecular Weight

411.51

Appearance

Solid

Formula

C23H25NO4S
CAS No.
SMILES

O=S(C1=CC=CC=C1)(OC2=CC=C(C=C2)NC(C34CC5CC(C4)CC(C3)C5)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (243.01 mM; ultrasonic and warming and heat to 50°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4301 mL 12.1504 mL 24.3007 mL
5 mM 0.4860 mL 2.4301 mL 4.8601 mL
10 mM 0.2430 mL 1.2150 mL 2.4301 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 2.5 mg/mL (6.08 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Enpp/Carbonic anhydrase-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Enpp/Carbonic anhydrase-IN-12883495-35-8ApoptosisCarbonic AnhydrasePhosphodiesterase (PDE)Carbonate dehydrataseantiproliferative activitylow cytotoxicK-562 cellsapoptosisInhibitorinhibitorinhibit

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