JNJ-39729209

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JNJ-39729209 is an antagonist for transient receptor potential vanilloid 1 (TRPV1) with pIC₅₀ of 7.9, 8.5, 7.9 and 7.7 for TRPV1 from human, rat, canine and guinea pig. JNJ-39729209 inhibits Capsaicin (HY-10448)-induced hypotension and inhibit thereby hypothermia. JNJ-39729209 exhibits anti-inflammatory and analgesic activities in Carrageenan (HY-125474)- and CFA (HY-153808)-induced thermal hyperalgesia rat models. JNJ-39729209 exhibits anti-cough effects in guinea pigs.

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JNJ-39729209 Estructura química

No. CAS : 1160606-90-5

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Ver todos los productos específicos de isoformas TRP Channel:

Ver todas las isoformas

TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

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Descripciòn	JNJ-39729209 is an antagonist for transient receptor potential vanilloid 1 (TRPV1) with pIC₅₀ of 7.9, 8.5, 7.9 and 7.7 for TRPV1 from human, rat, canine and guinea pig. JNJ-39729209 inhibits Capsaicin (HY-10448)-induced hypotension and inhibit thereby hypothermia. JNJ-39729209 exhibits anti-inflammatory and analgesic activities in Carrageenan (HY-125474)- and CFA (HY-153808)-induced thermal hyperalgesia rat models. JNJ-39729209 exhibits anti-cough effects in guinea pigs^[1].
Peso molecular	455.28
Fòrmula	C₁₉H₁₁Cl₂F₃N₄S
No. CAS	1160606-90-5
SMILES	FC(C1=CC=C(NC2=C3C(SC(CC4=C(Cl)C=CC=C4Cl)=N3)=NC=N2)C=C1)(F)F
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (273 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Maher MP, et al., Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist. Eur J Pharmacol. 2011 Aug 1;663(1-3):40-50. [Content Brief]

JNJ-39729209 Related Classifications

Neurological Disease Inflammation/Immunology

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-397292091160606-90-5JNJ39729209JNJ 39729209TRP ChannelTransient receptor potential channelsguinea pighypothermiahypotensionthermal hyperalgesiaSprague-Dawley ratInhibitorinhibitorinhibit

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JNJ-39729209

JNJ-39729209 Related Antibodies

Recomendaciones destacadas

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas TRP Channel:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

JNJ-39729209 Related Classifications

Calculadora de molaridad

Calculadora de dilución