KRAS G12D inhibitor 3 TFA

Cat. No.: HY-115880A Purity: 98.18%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

KRAS G12D inhibitor 3 TFA is a KRAS G12D inhibitor with an IC₅₀ of <500 nM. KRAS G12D inhibitor 3 TFA has antitumor effects (WO2022002102A1; compound 146). KRAS G12D inhibitor 3 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

KRAS G12D inhibitor 3 TFA 화학구조

CAS No. : 2757095-12-6

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of KRAS G12D inhibitor 3 TFA:

KRAS G12D inhibitor 3 견적 받기

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ras Isoform Specific Products:

View All Isoforms

K-Ras H-Ras N-Ras Ras

Biological Activity
순도&문서
References
고객리뷰

제품 설명

KRAS G12D inhibitor 3 TFA is a KRAS G12D inhibitor with an IC₅₀ of <500 nM. KRAS G12D inhibitor 3 TFA has antitumor effects (WO2022002102A1; compound 146)^[1]. KRAS G12D inhibitor 3 (TFA) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target^[1]

KRas G12D

<500 nM (IC₅₀)

분자량

748.11

화학식

C₃₆H₃₂ClF₆N₅O₄

CAS No.

2757095-12-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

C#CC1=C(C=CC2=C1C(C3=C(C4=C(C(N5CC6CCC(N6)C5)=NC(OC[C@@]78CCCN7C[C@@H](C8)F)=N4)C=C3Cl)F)=CC(O)=C2)F.OC(C(F)(F)F)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (133.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3367 mL	6.6835 mL	13.3670 mL
5 mM	0.2673 mL	1.3367 mL	2.6734 mL
10 mM	0.1337 mL	0.6684 mL	1.3367 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.18%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (252 KB) HNMR (324 KB) CNMR (293 KB) RP-HPLC (244 KB) LCMS (144 KB)

Handling Instructions (2659 KB)

References

[1]. Xing DAI, et al. Quinazoline compounds, preparation methods and uses thereof. WO2022002102A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3367 mL	6.6835 mL	13.3670 mL	33.4175 mL
	5 mM	0.2673 mL	1.3367 mL	2.6734 mL	6.6835 mL
	10 mM	0.1337 mL	0.6684 mL	1.3367 mL	3.3418 mL
	15 mM	0.0891 mL	0.4456 mL	0.8911 mL	2.2278 mL
	20 mM	0.0668 mL	0.3342 mL	0.6684 mL	1.6709 mL
	25 mM	0.0535 mL	0.2673 mL	0.5347 mL	1.3367 mL
	30 mM	0.0446 mL	0.2228 mL	0.4456 mL	1.1139 mL
	40 mM	0.0334 mL	0.1671 mL	0.3342 mL	0.8354 mL
	50 mM	0.0267 mL	0.1337 mL	0.2673 mL	0.6684 mL
	60 mM	0.0223 mL	0.1114 mL	0.2228 mL	0.5570 mL
	80 mM	0.0167 mL	0.0835 mL	0.1671 mL	0.4177 mL
	100 mM	0.0134 mL	0.0668 mL	0.1337 mL	0.3342 mL