2. Anti-infection Neuronal Signaling Immunology/Inflammation GPCR/G Protein
  3. Penicillin-binding protein (PBP) Bacterial Antibiotic Histamine Receptor
  4. Methicillin

Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis.

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Methicillin

Methicillin Chemical Structure

CAS No. : 61-32-5

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Other In-stock Forms of Methicillin:

Other Forms of Methicillin:

Methicillin Related Antibodies

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Description

Methicillin is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins.Methicillin can be used for the research of skin infections, osteomyelitis, and endocarditis[1].

IC50 & Target

β-lactam

 

Cellular Effect
Cell Line Type Value Description References
CHO IC50
116 3
Compound: Methicillin
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
[PMID: 23344796]
CHO IC50
116 3
Compound: Methicillin
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
[PMID: 23344796]
Vero CC50
> 200 3
Compound: Methicillin
Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
[PMID: 27036520]
Vero CC50
>200 3
Compound: Methicillin
Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
[PMID: 27036520]
In Vitro

Methicillin (20 μg/mL, 24 h) results in a rapid decrease in CFU of S. aureus[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methicillin Related Antibodies
In Vivo

Methicillin (Intramuscular administration, 40 mg/kg every 6 h, 5 days), in S. aureus.-infected rabbits[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
Masse moléculaire

380.42

Formule

C17H20N2O6S
CAS No.
SMILES

OC([C@@H]1N(C2=O)[C@@](SC(C)1C)([H])[C@@H]2NC(C(C(OC)=CC=C3)=C3OC)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Methicillin Related Classifications

  • Calculateur de molarité

  • Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methicillin61-32-5Penicillin-binding protein (PBP)BacterialAntibioticHistamine Receptorβ-lactam antibioticpenicillin-binding proteinskin infectionsStaphylococcus epidermidisMRSA.Inhibitorinhibitorinhibit

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