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Methicillin sodium hydrate

7 Cited Publications

Customer Review

Based on 7 publication(s) in Google Scholar

Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis.

For research use only. We do not sell to patients.

CAS No.: 7246-14-2
Formula: C₁₇H₂₁N₂NaO₇S
Molecular Weight:420.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Methicillin sodium hydrate Chemical Structure

CAS No.: 7246-14-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (7)
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target

β-lactam

All Antibiotic Isoforms :

All Histamine Receptor Isoforms :

In Vitro

Methcillin sodium hydrate (20 μg/mL, 24 h) results in a rapid decrease in CFU of S. aureus^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Methicillin sodium hydrate (Intramuscular administration, 40 mg/kg every 6 h, 5 days), in S. aureus.-infected rabbits^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 7246-14-2
Molecular Weight 420.41
Formula C₁₇H₂₁N₂NaO₇S
SMILES

O=C(O[Na])[C@H](N1C2=O)C(C)(S[C@@]1([C@@H]2NC(C3=C(C=CC=C3OC)OC)=O)[H])C.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (7)

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Journal Impact Factor

Chem Eng J

2026 Jan 19;529:173215.
Nano Today

2024 Dec.
Nano Today

2022, 47: 101683.
Sci Rep

Anandamide alters the membrane properties, halts the cell division and prevents drug efflux in multidrug resistant Staphylococcus aureus. [Abstract]

2021 Apr 22;11(1):8690. PMID: 33888802

Methicillin sodium hydrate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Disc diffusion assay using circled Whatman paper containing 50 μg of the indicated antibiotics. M Methicillin sodium salt, G Gentamicin, E Erythromycin.

Methicillin sodium hydrate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

The susceptibility of planktonic growing bacteria to increasing doses of Methicillin sodium salt (0-100 μg/mL). The OD_{595 nm} of the samples was measured after a 24 h incubation.

Methicillin sodium hydrate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

The survival of planktonic growing MDRSA CI-M in the absence or presence of 50 μg/ml Methicillin (Methicillin sodium salt) and increasing concentrations of AEA.

Methicillin sodium hydrate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

A kinetic study of the planktonic growth of MDRSA CI-M in the absence or presence of 50 μg/ml AEA and/or 50 μg/ml Methicillin sodium salt for 20 h.

Methicillin sodium hydrate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Biofilm formation after a 24 h incubation of MDRSA CI-M in the absence or presence of 25 or 50 μg/ml Methicillin sodium salt and increasing concentrations of AEA as measured by crystal violet staining.
Biomed Res Int

In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]

2018 Jul 2:2018:3579832. PMID: 30065936
bioRxiv

2025 Oct 27.
Research Square Print

October 6th, 2022.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sharon S. Castle. Methicillin. xPharm: The Comprehensive Pharmacology Reference 2007, Pages 1-4.

[2]. Jaime Carrizosa, et al. Treatment of Experimental Staphylococcus aureus Endocarditis: Comparison of Cephalothin, Cefazolin, and Methicillin. Antimicrob Agents Chemother. 1978 Jan; 13(1): 74–77.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Methicillin sodium hydrate

7 Cited Publications

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Methicillin sodium hydrate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Customer Validation
Disc diffusion assay using circled Whatman paper containing 50 μg of the indicated antibiotics. M Methicillin sodium salt, G Gentamicin, E Erythromycin.

1/16

Methicillin sodium hydrate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Customer Validation
The susceptibility of planktonic growing bacteria to increasing doses of Methicillin sodium salt (0-100 μg/mL). The OD_{595 nm} of the samples was measured after a 24 h incubation.

1/16

Methicillin sodium hydrate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Customer Validation
The survival of planktonic growing MDRSA CI-M in the absence or presence of 50 μg/ml Methicillin (Methicillin sodium salt) and increasing concentrations of AEA.

1/16

Methicillin sodium hydrate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Customer Validation
A kinetic study of the planktonic growth of MDRSA CI-M in the absence or presence of 50 μg/ml AEA and/or 50 μg/ml Methicillin sodium salt for 20 h.

1/16

Methicillin sodium hydrate purchased from MedChemExpress. Usage Cited in: Sci Rep. 2021 Apr 22;11(1):8690. [Abstract]

Customer Validation
Biofilm formation after a 24 h incubation of MDRSA CI-M in the absence or presence of 25 or 50 μg/ml Methicillin sodium salt and increasing concentrations of AEA as measured by crystal violet staining.

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Methicillin sodium hydrate

Publications Citing Use of MedChemExpress (MCE) Methicillin sodium hydrate

All Antibiotic Isoforms

All Histamine Receptor Isoforms