2. Apoptosis Epigenetics Protein Tyrosine Kinase/RTK
  3. Apoptosis Histone Methyltransferase FLT3
  4. (S)-Bleximenib oxalate

(S)-Bleximenib oxalate  (Synonyms: (S)-JNJ-75276617 oxalate; (S)-Menin-MLL inhibitor 24 oxalate)

Art. -Nr.: HY-148669B Reinheit: 98.37%
COA
SDS
Handling Instructions Technical Support

(S)-Bleximenib (oxalate) is a S-Enantiomer of Bleximenib oxalate (HY-148669A). Bleximenib (JNJ-75276617) oxalate is an orally active and selective menin-KMT2A inhibitor, with IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. Bleximenib oxalate can inhibit the proliferation and induce apoptosis and differentiation of tumor cells. Bleximenib oxalate can be used in the research of tumors such as leukemia.

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(S)-Bleximenib oxalate

(S)-Bleximenib oxalate Chemische Struktur

Größe Preis Verfügbarkeit Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 Auf Lager
Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
5 mg Auf Lager
10 mg Auf Lager
25 mg Auf Lager
50 mg Auf Lager
100 mg Auf Lager
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500 mg   Angebot einholen  

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Other Forms of (S)-Bleximenib oxalate:

(S)-Bleximenib oxalate Related Antibodies

Top Publications Citing Use of Products

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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  • Reinheit & Dokumentation

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Beschreibung

(S)-Bleximenib (oxalate) is a S-Enantiomer of Bleximenib oxalate (HY-148669A). Bleximenib (JNJ-75276617) oxalate is an orally active and selective menin-KMT2A inhibitor, with IC50 values of 0.1 nM, 0.045 nM, and ≤0.066 nM for humans, mice, and dogs, respectively. Bleximenib oxalate can inhibit the proliferation and induce apoptosis and differentiation of tumor cells. Bleximenib oxalate can be used in the research of tumors such as leukemia[1].

Molekulargewicht

689.82

Formel

C34H52FN7O7
Appearance

Solid

Color

Off-white to light yellow

SMILES

COCCN(C)CCC[C@H](N1CC2(C1)CN(C3=NC=NN=C3OC4=C(C=C(C=C4)F)C(N(CC)C(C)C)=O)CC2)C(C)C.O=C(O)C(O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 100 mg/mL (144.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4497 mL 7.2483 mL 14.4965 mL
5 mM 0.2899 mL 1.4497 mL 2.8993 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 98.37%

SDS (252 KB)

COA (252 KB) HNMR (332 KB) RP-HPLC (164 KB) LCMS (118 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4497 mL 7.2483 mL 14.4965 mL 36.2413 mL
5 mM 0.2899 mL 1.4497 mL 2.8993 mL 7.2483 mL
10 mM 0.1450 mL 0.7248 mL 1.4497 mL 3.6241 mL
15 mM 0.0966 mL 0.4832 mL 0.9664 mL 2.4161 mL
20 mM 0.0725 mL 0.3624 mL 0.7248 mL 1.8121 mL
25 mM 0.0580 mL 0.2899 mL 0.5799 mL 1.4497 mL
30 mM 0.0483 mL 0.2416 mL 0.4832 mL 1.2080 mL
40 mM 0.0362 mL 0.1812 mL 0.3624 mL 0.9060 mL
50 mM 0.0290 mL 0.1450 mL 0.2899 mL 0.7248 mL
60 mM 0.0242 mL 0.1208 mL 0.2416 mL 0.6040 mL
80 mM 0.0181 mL 0.0906 mL 0.1812 mL 0.4530 mL
100 mM 0.0145 mL 0.0725 mL 0.1450 mL 0.3624 mL
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(S)-Bleximenib oxalate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Bleximenib(S)-JNJ-75276617(S)-Menin-MLL inhibitor 24ApoptosisHistone MethyltransferaseFLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3CancerleukemiaMeninMLLInhibitorinhibitorinhibit

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