2. Anti-infection Cell Cycle/DNA Damage
  3. Antibiotic Bacterial DNA/RNA Synthesis
  4. Sarecycline

Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne.

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CAS 番号 : 1035654-66-0

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Sarecycline 関連抗体

Top Publications Citing Use of Products

    Sarecycline purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2023 Feb 14;11(1):e0323822.  [Abstract]

    The MIC distributions of Sarecycline against 43 M. fortuitum isolates. The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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    製品説明

    Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne[1][2][3][4][5][6].

    IC50 & Target

    Tetracycline

     

    体外実験

    Sarecycline inhibits 55 clinical isolates of C. acnes, and the MIC values for Sarecycline ranged from 0.5 to 16  µg/ml; the MIC50 was 0.5 µg/ml, and the MIC90 was 4 µg/ml[1].
    Sarecycline exhibits activity against the macrolide-resistant organisms[1].
    Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Sarecycline 関連抗体
    体内実験

    Sarecycline hydrochloride (0.33-9  mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1].
    Sarecycline can inhibit S. aureus (PD50=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection[6].
    Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Carrageenan-induced footpad edema male Sprague Dawley rats model[6]
    Dosage: 1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg
    Administration: Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.
    Result: Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.
    Animal Model: Carrageenan-induced footpad edema male Sprague Dawley rats model[6]
    Dosage: 0.33, 1, 3, or 9 mg/kg
    Administration: Intravenously
    Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32 mg/kg, respectively.
    分子量

    487.50

    分子式

    C24H29N3O8
    CAS 番号
    SMILES

    O[C@@](C(O)=C(C(C1=C(C=C2)O)=O)[C@](CC1=C2CN(C)OC)([H])C3)(C(C(C(N)=O)=C4O)=O)[C@]3([H])[C@@H]4N(C)C
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
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    参考文献
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    Sarecycline Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sarecycline1035654-66-0P-005672P005672P 005672AntibioticBacterialDNA/RNA SynthesisAcneInflammationTetracyclinetetracycline-classbacteriaanti-inflammatory70SribosomeInhibitorinhibitorinhibit

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