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Results for "

α-(1-2,3,6) Mannosidase

" in MedChemExpress (MCE) Product Catalog:

30

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2

Fluorescent Dyes

4

Biochemical Assay Reagents

6

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4

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1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19332
    Kifunensine
    Maximum Cited Publications
    13 Publications Verification

    FR-900494

    Glycosidase Inflammation/Immunology
    Kifunensine, a potent and selective inhibitor of class I α-mannosidases isolated from Actinomycete, prevents α-mannosidases I from trimming mannose residues on glycoproteins. Kifunensine inhibits ERAD .
    Kifunensine
  • HY-N6722
    Swainsonine
    1 Publications Verification

    Tridolgosir

    Apoptosis Antibiotic Infection Cancer
    Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity .
    Swainsonine
  • HY-W009783
    1-Deoxymannojirimycin hydrochloride
    1 Publications Verification

    HIV Influenza Virus Infection Cancer
    1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. 1-Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . 1-Deoxymannojirimycin hydrochloride increases high mannose structures. 1-Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer .
    1-Deoxymannojirimycin hydrochloride
  • HY-N1470

    Glycosidase Metabolic Disease
    Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC50 values of 5 μM and a Ki of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .
    Plantagoside
  • HY-P2950

    Glycosidase Metabolic Disease
    α-Mannosidase is a hydrolytic enzyme targeting mannose-containing glycoproteins or glycolipids. α-Mannosidase is promising for research of inherited α-mannosidosis .
    α-Mannosidase
  • HY-W009122

    4-Methylumbelliferyl-alpha-d-mannoside

    Biochemical Assay Reagents Others
    4-Methylumbelliferyl-α-d-mannoside is a fluorescent substrate for α-D-mannosidase.
    4-Methylumbelliferyl-α-d-mannoside
  • HY-P2950A

    Glycosidase Metabolic Disease
    α1-6 Mannosidase, Xanthomonas phaseoli is a highly specific exoglycosidase that removes unbranched α1-6 linked mannose residues from oligosaccharides .
    α1-6 Mannosidase, Xanthomonas phaseoli
  • HY-P2858

    Glycosidase Metabolic Disease
    β-Mannosidase is a lysosomal exo‑acting enzyme. β-Mannosidase catalyzes hydrolysis of β‑1,4‑linked mannosides, non‑reducing terminal mannoses in N‑glycoproteins, and Man‑β‑1,4‑GlcNAc linkages to release mannose. β-Mannosidase contributes to glycoprotein catabolism and supports Bifidobacteria colonization via N‑glycan depolymerization. β-Mannosidase can be used for the research of β-mannosidosis and β-mannosidase deficiency .
    β-Mannosidase
  • HY-P2950H

    Biochemical Assay Reagents Others
    exo-α-1,3-Mannosidase, Bacteroides thetaiotaomicron is a glycoside hydrolase that can hydrolyze mannose α-1,3 linkages in host N-glycans .
    exo-α-1,3-Mannosidase, Bacteroides thetaiotaomicron
  • HY-W357151

    Fluorescent Dye Others
    6-Chloro-3-indoxyl-α-D-mannopyranoside is a chromogenic substrate for α-mannosidase resulting in a salmon colored precipitate upon cleavage.
    6-Chloro-3-indoxyl-α-D-mannopyranoside
  • HY-P2950I

    Biochemical Assay Reagents Others
    exo-α-1,2-Mannosidase, Bacteroides thetaiotaomicron (EC.3.2.1.113) is a glycoside hydrolase involved in mannan decomposition .
    exo-α-1,2-Mannosidase, Bacteroides thetaiotaomicron
  • HY-P2950D

    Biochemical Assay Reagents Others
    exo-α-1,4-Mannosidase, Bacteroides thetaiotaomicron (EC.3.2.1.163) is a glycoside hydrolase involved in mannan decomposition .
    exo-α-1,4-Mannosidase, Bacteroides thetaiotaomicron
  • HY-P2950C

    Biochemical Assay Reagents Others
    exo-α-1,6-Mannosidase, Bacteroides thetaiotaomicron (EC.3.2.1.163) is a glycoside hydrolase that can hydrolyze mannose α-1,6 linkages in host N-glycans .
    exo-α-1,6-Mannosidase, Bacteroides thetaiotaomicron
  • HY-P2950K

    Biochemical Assay Reagents Others
    exo-α-Mannosidase, Bacteroides thetaiotaomicron (EC.3.2.1.24) is a glycoside hydrolase involved in mannan decomposition .
    exo-α-Mannosidase, Bacteroides thetaiotaomicron
  • HY-P2950B

    Biochemical Assay Reagents Others
    α-(1-2,3,6) Mannosidase is a glycosidase. Enzymes have high catalytic efficiency, high specificity, and mild operating conditions. It can be applied in industries such as pharmaceuticals, industrial production, food manufacturing, and aquaculture .
    α-(1-2,3,6) Mannosidase
  • HY-E70304

    MAN1A1

    Endogenous Metabolite Others
    Mannosyl-oligosaccharide 1,2-α-mannosidase IA (MAN1A1) is a glycosidase that catalyzes the hydrolysis of α-1,2-linked mannose residues in Man(9)GlcNAc(2) to produce Man(9)GlcNAc(2) .
    Mannosyl-oligosaccharide 1,2-α-mannosidase IA
  • HY-137496

    Biochemical Assay Reagents
    4-Methylumbelliferyl β-D-mannopyranoside is a substrate that exhibits β-mannosidase activity. 4-Methylumbelliferyl β-D-mannopyranoside can be used to study β-mannosidase deficiency. The reactivity of 4-Methylumbelliferyl β-D-mannopyranoside shows different inhibitory effects on various substrates.
    4-Methylumbelliferyl β-D-mannopyranoside
  • HY-W009783A

    HIV Influenza Virus Infection Cancer
    Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . Deoxymannojirimycin hydrochloride increases high mannose structures. Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer .
    Deoxymannojirimycin hydrochloride
  • HY-P2858A

    Glycosidase Metabolic Disease
    β-Mannosidase, Cellvibrio mixtus (EC 3.2.1.25), is the final exoglycosidase in the N-linked glycoprotein oligosaccharide catabolism pathway. β-Mannosidase catalyzes the following chemical reaction: hydrolysis of the terminal non-reducing β-D-mannose residue in β-D-mannoside.
    β-Mannosidase, Cellvibrio mixtus
  • HY-P2858C

    Glycosidase Metabolic Disease
    β-Mannosidase, Bacteroides fragilis (EC 3.2.1.25), is the final exoglycosidase in the N-linked glycoprotein oligosaccharide catabolism pathway. β-Mannosidase catalyzes the following chemical reaction: hydrolysis of the terminal non-reducing β-D-mannose residue in β-D-mannoside.
    β-Mannosidase, Bacteroides fragilis
  • HY-P2858B

    Glycosidase Metabolic Disease
    β-Mannosidase, Bacteroides thetaiotaomicron (EC 3.2.1.25), is the final exoglycosidase in the N-linked glycoprotein oligosaccharide catabolism pathway. β-Mannosidase catalyzes the following chemical reaction: hydrolysis of the terminal non-reducing β-D-mannose residue in β-D-mannoside.
    β-Mannosidase, Bacteroides thetaiotaomicron
  • HY-P2858E

    Biochemical Assay Reagents Metabolic Disease
    β-Mannosidase, Helix pomatia (EC 3.2.1.25), catalyzes the hydrolysis of the terminal non-reducing β-D-mannose residue in β-D-mannoside. β-Mannosidase, Helix pomatia (EC 3.2.1.25) is the final exoglycosidase in the N-linked glycoprotein oligosaccharide catabolism pathway.
    β-Mannosidase, Helix pomatia
  • HY-P2950L

    Glycosidase Metabolic Disease
    α1-2,3 Mannosidase, Xanthomonas manihotis is an acid hydrolase which is located in plant vacuoles and is thought to be involved with the turnover of N-linked glycoproteins.
    α1-2,3 Mannosidase, Xanthomonas manihotis
  • HY-E71168

    Biochemical Assay Reagents Others
    1,6-α-D-Mannosidase (EC 3.2.1.163) is specific for (1→6)-linked mannobiose and has no activity towards any other linkages, or towards p-nitrophenyl-α-D-mannopyranoside or baker's yeast mannan. It is strongly inhibited by Mn2+ but does not require Ca2+ or any other metal cofactor for activity.
    1,6-α-D-Mannosidase
  • HY-P2858H

    Biochemical Assay Reagents Others
    β-Mannosidase, Streptomyces coelicolor (EC 3.2.1.25) catalyses the following chemical reaction:Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides. This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.
    β-Mannosidase, Streptomyces coelicolor
  • HY-181175

    Glycosidase Metabolic Disease
    OMJ-4 is a mutant alpha-mannosidase modulator. OMJ-4 can restore mutant alpha-mannosidase's catalytic function, and induces changes in compactness and active-site flexibility to improve substrate accommodation. OMJ-4 acts as an inducer of substrate reactivity, increasing the reactivity of mannose disaccharide bound to mutant alpha-mannosidase. OMJ-4 reduces the activation energy required for the enzymatic reaction of mutant alpha-mannosidase. OMJ-4 can be used for the research of alpha-mannosidosis .
    OMJ-4
  • HY-W009783R

    Reference Standards HIV Influenza Virus Infection Cancer
    1-Deoxymannojirimycin (hydrochloride) (Standard) is the analytical standard of 1-Deoxymannojirimycin (hydrochloride) (HY-W009783). This product is intended for research and analytical applications. 1-Deoxymannojirimycin hydrochloride is a selective class I α1,2-mannosidase inhibitor with an IC50 of 20 μM. 1-Deoxymannojirimycin hydrochloride is also a N-linked glycosylation inhibitor. 1-Deoxymannojirimycin hydrochloride has antiviral activity against HIV‐1 strains . 1-Deoxymannojirimycin hydrochloride increases high mannose structures. 1-Deoxymannojirimycin hydrochloride can be used for the study of liver cancer and colon cancer .
    1-Deoxymannojirimycin hydrochloride (Standard)
  • HY-179631

    Apoptosis Cancer
    2DG-ODDA is a 2-deoxyglucose (2-DG) (HY-13966) derivative with potent antitumor activity. 2DG-ODDA induces apoptosis, and reduces ATP production. 2DG-ODDA is taken up through both fatty acid and glucose transporters and is cleaved by α-Mannosidase (HY-P2950), releases 2DG to inhibit N-glycosylation and disrupt cellular metabolism. 2DG-ODDA inhibits tumor growth in a 4T1 mouse model. 2DG-ODDA can be used for the research of triple-negative breast cancer (TNBC) .
    2DG-ODDA
  • HY-N1470R

    Reference Standards Glycosidase Metabolic Disease
    Plantagoside (Standard) is the analytical standard of Plantagoside (HY-N1470). This product is intended for research and analytical applications. Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC50 values of 5 μM and a Ki of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .
    Plantagoside (Standard)
  • HY-D3187

    Fluorescent Dye Glycosidase Infection Cancer
    HMRef-αMan is a substrate-based green fluorescent probe (Ex/Em=465 nm/515 nm) targeting MAN2C1 (α-mannosidase). HMRef-αMan can be specifically cleaved by MAN2C1 to generate a highly fluorescent product, which thus gets activated to produce green fluorescence in malignant breast tissues, benign lesions and living cancer cells. The signal intensity of HMRef-αMan is directly correlated with MAN2C1 activity, and it can effectively detect tiny breast cancer lesions with a diameter of less than 1 mm. When used in combination with the red-emitting γ-glutamyl transpeptidase (GGT) probe gGlu-2OMe SiR600 (HY-D3188), HMRef-αMan enables precise optical differentiation of breast tissue types via a dual-color imaging strategy. HMRef-αMan has been widely used in the research of breast diseases such as breast cancer, fibroadenoma, phyllodes tumor and various types of papilloma .
    HMRef-αMan

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