Swainsonine (Synonyms: Tridolgosir)

Cat. No.: HY-N6722 Purity: ≥98.00%: FAQs
Data Sheet SDS COA Handling Instructions

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Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.

For research use only. We do not sell to patients.

Swainsonine Chemical Structure

CAS No. : 72741-87-8

Size	Price	Stock	Quantity
1 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 900	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Description

In Vitro

Swainsonine (0-40 μM; 12 h) shows antiproliferative activity in U251 and LN444 cells^[2].
Swainsonine (30 μM; 12 h) induces apoptosis and cell cycle arrest at G2/M phase, and decreases the expression of CyclinD1 and CDK4 protein levels, increases the expression of p16 protein level^[2].
Swainsonine (30 μM; 12 h) reduces glioma cell migration and invasion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	U251, LN444 cells
Concentration:	0, 10, 20, 30, 40 µM
Incubation Time:	12 h
Result:	Inhibited cell viability in a dose-dependent manner, and shows no cytotoxicity in normal brain cells.

Cell Cycle Analysis^[2]

Cell Line:	U251 cells
Concentration:	30 µM
Incubation Time:	12 h
Result:	Induced cell cycle arrest at G2/M phase.

Apoptosis Analysis^[2]

Cell Line:	U251 cells
Concentration:	30 µM
Incubation Time:	12 h
Result:	Induced apoptosis with the cleaved-Caspase-3 and cleaved-Caspase-9 expression were obviously increased.

In Vivo

Swainsonine (1 mg/kg; i.p.; twice daily for ten days) and cisplatin increases the anti-tumor efficacy in mouse^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eighty-seven sixty-day-old male C57BL/6 mice^[3]
Dosage:	1 mg/kg (cisplatin; 0.25 mg/kg, i.p., every other day for 10 days)
Administration:	I.p.; twice daily for ten days
Result:	Showed a significant reduction in ascites volume of 63.5% was observed in mice and a significant reduction in the percentage of cells in the G0/G1, S and G2 phases.

Molecular Weight

173.21

Formula

C₈H₁₅NO₃

CAS No.

72741-87-8

Appearance

Solid

Color

Light yellow to brown

SMILES

O[C@@H]1[C@H](O)CN2CCC[C@@H](O)[C@]12[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 10 mg/mL (57.73 mM; Need ultrasonic and warming)

DMSO : 10 mg/mL (57.73 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 3.57 mg/mL (20.61 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.7733 mL	28.8667 mL	57.7334 mL
5 mM	1.1547 mL	5.7733 mL	11.5467 mL
10 mM	0.5773 mL	2.8867 mL	5.7733 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (278 KB) SDS (393 KB)

COA (252 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / Ethanol / DMSO	1 mM	5.7733 mL	28.8667 mL	57.7334 mL	144.3335 mL
	5 mM	1.1547 mL	5.7733 mL	11.5467 mL	28.8667 mL
	10 mM	0.5773 mL	2.8867 mL	5.7733 mL	14.4333 mL
	15 mM	0.3849 mL	1.9244 mL	3.8489 mL	9.6222 mL
	20 mM	0.2887 mL	1.4433 mL	2.8867 mL	7.2167 mL
Ethanol / DMSO	25 mM	0.2309 mL	1.1547 mL	2.3093 mL	5.7733 mL
	30 mM	0.1924 mL	0.9622 mL	1.9244 mL	4.8111 mL
	40 mM	0.1443 mL	0.7217 mL	1.4433 mL	3.6083 mL
	50 mM	0.1155 mL	0.5773 mL	1.1547 mL	2.8867 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Swainsonine72741-87-8TridolgosirInhibitorinhibitorinhibit

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