72741-87-8
72741-87-8
Chemical Structure
Swainsonine
Synonym(s): Tridolgosir
- CAS No.: 72741-87-8
- Formula:C8H15NO3
- Molecular Weight:173.21
IUPAC Name: (1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol
InChIKey: FXUAIOOAOAVCGD-WCTZXXKLSA-N
SMILES: O[C@@H]1[C@H](O)CN2CCC[C@@H](O)[C@]12[H]
Biological Activity: Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity[1][2][3].
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Swainsonine | 99.95% | Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity. | ||||||||||||||||||||
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References
- [1]. Dorling PR, et al. Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. Biochem J. 1980 Nov 1;191(2):649-51. [Content Brief]
- [2]. Sun L, et al. Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression. BMC Cancer. 2019 Mar 19;19(1):247. doi: 10.1186/s12885-019-5425-7. [Content Brief]
- [3]. Santos FM, et al. Increased antitumor efficacy by the combined administration of swainsonine and cisplatin in vivo. Phytomedicine. 2011 Sep 15;18(12):1096-101. [Content Brief]
Keywords
