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Results for "

2DG

" in MedChemExpress (MCE) Product Catalog:

21

Inhibitors & Agonists

3

Natural
Products

4

Isotope-Labeled Compounds

1

Antibodies

7

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13966
    2-Deoxy-D-glucose
    340+ Cited Publications

    2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose

    		 Hexokinase HSV Apoptosis Cancer
    2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .
    2-Deoxy-D-glucose
  • HY-N2040
    (20R)-Protopanaxadiol
    1 Publications Verification

    		 Bacterial Interleukin Related Infection Inflammation/Immunology Cancer
    (20R)-Protopanaxadiol is a metabolite of ginsenosides. (20R)-Protopanaxadiol has anti-inflammatory and antibacterial activities, but shows no significant cytotoxicity against tumor cell lines. In addition, (20R)-Protopanaxadiol can inhibit the uptake of 2-deoxy-D-glucose (2-DG) [2] .
    (20R)-Protopanaxadiol
  • HY-148009
    Cardiolipin (16:0/18:1/16:0/18:1) sodium

    16:0-18:1 Cardiolipin sodium

    		 Biochemical Assay Reagents Others
    Cardiolipin (16:0/18:1/16:0/18:1) (16:0-18:1 Cardiolipin) sodium is a di-saturated mitochondrial-specific anionic phospholipid sodium salt containing the long-chain fatty acid palmitic acid (HY-N0830) and the monounsaturated fatty acid oleic acid (HY-N1446). Cardiolipin (16:0/18:1/16:0/18:1) sodium undergoes in-source fragmentation via diglyceride (DG)-H2O fragment formation and (DG-H2O) fragment loss pathways. Cardiolipin (16:0/18:1/16:0/18:1) sodium can be used in the synthesis of lipid nanodiscs for application in in situ mass spectrometry .
    Cardiolipin (16:0/18:1/16:0/18:1) sodium
  • HY-139409A
    2-Deoxy-D-glucose 6-phosphate disodium
    2 Publications Verification

    		 Hexokinase Glucose-6-Phosphate Isomerase (GPI) Cancer
    2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research [2].
    2-Deoxy-D-glucose 6-phosphate disodium
  • HY-13966S
    2-Deoxy-D-glucose-d1
    1 Publications Verification

    2-DG-d1; 2-Deoxy-D-arabino-hexose-d1; D-Arabino-2-deoxyhexose-d1

    		 Isotope-Labeled Compounds Apoptosis Hexokinase HSV Cancer
    2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase [2].
    2-Deoxy-D-glucose-d1
  • HY-154602
    2’-dG (iBu)-2’-phosphoramidite

    		Nucleoside Antimetabolite/Analog Phosphoramidites Cancer
    2’-dG (iBu)-2’-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    2’-dG (iBu)-2’-phosphoramidite
  • HY-116930
    S-20928

    		Melatonin Receptor Metabolic Disease
    S-20928 is an antagonist for melatonin receptor through inhibition of binding of melatonin to its receptors. S-20928 enhances the 2-Deoxy-D-glucose (2DG) (HY-13966)-induced increase in blood glucose and glucagon levels in rats brain .
    S-20928
  • HY-159728
    PROTAC PRMT3 degrader 1

    		PROTACs Histone Methyltransferase Apoptosis Early 2 Factor (E2F) c-Myc Cancer
    PROTAC PRMT3 degrader 1 is a selective PRMT3 PROTAC degrader with a DC50 of 2.566 μM. PROTAC PRMT3 degrader 1 forms a ternary complex with MDM2 E3 ubiquitin ligase to induce proteasomal and neddylation-dependent degradation of PRMT3. PROTAC PRMT3 degrader 1 activates intrinsic apoptosis, endoplasmic reticulum stress signaling pathways. PROTAC PRMT3 degrader 1 downregulates E2F, MYC, oxidative phosphorylation pathways. PROTAC PRMT3 degrader 1 reduces cellular asymmetric dimethylarginine (ADMA) levels. PROTAC PRMT3 degrader 1 inhibits acute leukemia cell growth. PROTAC PRMT3 degrader 1 acts with glycolysis inhibitor 2-DG to reduce ATP production, induce intrinsic apoptosis, drive synergistic antiproliferative effects. PROTAC PRMT3 degrader 1 can be used for the research of acute leukemia .
    PROTAC PRMT3 degrader 1
  • HY-13966S2
    2-Deoxy-D-glucose-13C

    2-DG-13C; 2-Deoxy-D-arabino-hexose-13C; D-Arabino-2-deoxyhexose-13C

    		 Isotope-Labeled Compounds Apoptosis Hexokinase HSV Cancer
    2-Deoxy-D-glucose- 13C is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase [2].
    2-Deoxy-D-glucose-13C
  • HY-N16321
    C18:0 DG-PEG2K-triGalNAc

    		Biochemical Assay Reagents Others
    C18:0 DG-PEG2K-triGalNAc is a functionalized PEG lipid that consists of a C18:0 DG unit conjugated to a triGalNAc. C18:0 DG-PEG2K-triGalNAc can be used to prepare lipid nanoparticles for drug delivery.
    C18:0 DG-PEG2K-triGalNAc
  • HY-139409
    2-Deoxy-D-glucose 6-phosphate

    		Hexokinase Glucose-6-Phosphate Isomerase (GPI) Cancer
    2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive and 2-deoxy-D-glucose non-competitive Hexokinase inhibitor, with a Ki value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the generation and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research [2].
    2-Deoxy-D-glucose 6-phosphate
  • HY-13966S3
    2-Deoxy-D-glucose-13C6

    2-DG-13C6; 2-Deoxy-D-arabino-hexose-13C6; D-Arabino-2-deoxyhexose-13C6

    		 Isotope-Labeled Compounds Apoptosis Hexokinase HSV Cancer
    2-Deoxy-D-glucose- 13C6 (2-DG- 13C6) is 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase [2].
    2-Deoxy-D-glucose-13C6
  • HY-179631
    2DG-ODDA

    		Apoptosis Cancer
    2DG-ODDA is a 2-deoxyglucose (2-DG) (HY-13966) derivative with potent antitumor activity. 2DG-ODDA induces apoptosis, and reduces ATP production. 2DG-ODDA is taken up through both fatty acid and glucose transporters and is cleaved by α-Mannosidase (HY-P2950), releases 2DG to inhibit N-glycosylation and disrupt cellular metabolism. 2DG-ODDA inhibits tumor growth in a 4T1 mouse model. 2DG-ODDA can be used for the research of triple-negative breast cancer (TNBC) .
    2DG-ODDA
  • HY-176051
    Rapaglutin E

    RgE

    		 GLUT Cancer
    Rapaglutin E (RgE) is a glucose transporter (GLUT) inhibitor. Rapaglutin E exhibits dose-dependent inhibition of [ 3H]-2DG uptake in A549, Jurkat T, PANC10.05, and RBC, with IC50 values 8.9 nM, 3.1 nM, 35.5 nM, 74.2 nM. Rapaglutin E inhibits cell proliferation in A549, PANC10.05, HeLa, Jurkat T, and HEK293T cells .
    Rapaglutin E
  • HY-13966S4
    2-Deoxy-D-glucose-13C-1

    2-DG-13C-1; 2-Deoxy-D-arabino-hexose-13C-1; D-Arabino-2-deoxyhexose-13C-1

    		 Isotope-Labeled Compounds Apoptosis Hexokinase HSV Cancer
    2-Deoxy-D-glucose- 13C-1 is the 13C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase [2].
    2-Deoxy-D-glucose-13C-1
  • HY-139409B
    2-Deoxy-D-glucose 6-phosphate sodium

    		Drug Derivative Metabolic Disease
    2-Deoxy-D-glucose 6-phosphate sodium, a derivative of 2-Deoxy-D-glucose (HY-13966), is produced in mammalian cells by the action of hexokinase on 2-DG. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase [2].
    2-Deoxy-D-glucose 6-phosphate sodium
  • HY-178590
    3'-O-Phthalimido-2'-dG

    		Nucleoside Antimetabolite/Analog Metabolic Disease
    3'-O-Phthalimido-2'-dG is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-Phthalimido-2'-dG
  • HY-W048518
    7-Deaza-2'-dG

    7-Deaza-2'-deoxyguanosine

    		 Nucleoside Antimetabolite/Analog Metabolic Disease
    7-Deaza-2'-dG (7-Deaza-2'-deoxyguanosine) is a monomeric raw material that can be used for nucleic acid synthesis.
    7-Deaza-2'-dG
  • HY-W1008068
    3'-O-TBDMS-2'-dG(iBu)

    		Nucleoside Antimetabolite/Analog Metabolic Disease
    3'-O-TBDMS-2'-dG(iBu) is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-TBDMS-2'-dG(iBu)
  • HY-178637
    3'-O-NH2-2'-dG

    		Nucleoside Antimetabolite/Analog Metabolic Disease
    3'-O-NH2-2'-dG is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-NH2-2'-dG
  • HY-178621
    DMTr-2'-dG(iBu)-3'-S-CE-phosphoramidite

    		Nucleoside Antimetabolite/Analog Phosphoramidites Metabolic Disease
    DMTr-2'-dG(iBu)-3'-S-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-dG(iBu)-3'-S-CE-phosphoramidite

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