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Results for "

ATG16L1

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

3

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100008
    Peretinoin
    5+ Cited Publications

    NIK333

    		 RAR/RXR SphK Autophagy HCV Infection Cancer
    Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1 . Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression . Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM .
    Peretinoin
  • HY-170998
    ATG16L1 stabilizer-1

    		Autophagy Inflammation/Immunology
    ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent ATG16L1 stabilizer that promotes cellular Autophagy. ATG16L1 stabilizer-1 inhibits ATG16L1 with an EC50 of 12.1 μM in the presence or absence of FKBP12. ATG16L1 stabilizer-1 alone induces GFP-LC3 puncta formation to a small extent with an EC50 of 12.0 μM .
    ATG16L1 stabilizer-1
  • HY-RS26329
    Atg16l1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Atg16l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Atg16l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Atg16l1 Rat Pre-designed siRNA Set A
    Atg16l1 Rat Pre-designed siRNA Set A
  • HY-RS01143
    ATG16L1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ATG16L1 Human Pre-designed siRNA Set A contains three designed siRNAs for ATG16L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ATG16L1 Human Pre-designed siRNA Set A
    ATG16L1 Human Pre-designed siRNA Set A
  • HY-RS19832
    Atg16l1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Atg16l1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atg16l1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Atg16l1 Mouse Pre-designed siRNA Set A
    Atg16l1 Mouse Pre-designed siRNA Set A
  • HY-183826
    ATG5 PPI-IN-4

    		Autophagy Infection Cancer
    ATG5 PPI-IN-4 is an autophagy inhibitor targeting ATG5, with an IC50 of 12.78 μM against ATG5-ATG16L1 and an IC50 of 12.00 μM against ATG5-TECAIR. ATG5 PPI-IN-4 blocks the protein interactions between ATG5 and ATG16L1, as well as between ATG5 and TECAIR, disrupts the assembly of the ATG12-ATG5-ATG16L1 ternary complex, inhibits the lipidation modification of LC3/ATG8, and ultimately downregulates cellular autophagy levels. ATG5 PPI-IN-4 can be used in autophagy-related research, such as studies on infection and cancer .
    ATG5 PPI-IN-4
  • HY-183736
    Autophagy-IN-12

    		Others
    Autophagy-IN-12 (Compound 17e) is a autophagy inhibitor. Autophagy-IN-12 exhibits an IC50 value of >33 μM against the protein-protein interactions of ATG5-ATG16L1 and ATG5-TECAIR .
    Autophagy-IN-12
  • HY-183731
    ATG5 PPI-IN-1

    		Autophagy Others
    ATG5 PPI-IN-1 (Compound 17b) is a ATG5 protein-protein interaction inhibitor, with an IC50 of 27.43 μM for the ATG5-ATG16L1 interaction and an IC50 of 14.88 μM for the ATG5-TECAIR interaction .
    ATG5 PPI-IN-1
  • HY-100008R
    Peretinoin (Standard)

    NIK333 (Standard)

    		 Reference Standards RAR/RXR SphK Autophagy HCV Infection Cancer
    Peretinoin (Standard) is the analytical standard of Peretinoin. This product is intended for research and analytical applications. Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 μM[3].
    Peretinoin (Standard)
  • HY-183835
    Autophagy-IN-10

    		Autophagy Others
    Autophagy-IN-10 (Compound 12a) is an Autophagy inhibitor and an inhibitor of ATG5 interaction with other proteins, with an IC50 value of 2.29 μM against ATG5-ATG16L1 and an IC50 value of 3.68 μM against ATG5-TECAIR .
    Autophagy-IN-10
  • HY-183730
    4E1RCat 17d

    		Autophagy Drug Derivative Others
    4E1RCat 17d (Compound 17d) is a derivative of the ATG5 inhibitor lead compound T1742. 4E1RCat 17d shows no activity against the interactions of ATG5-ATG16L1 and ATG5-TECAIR. 4E1RCat 17d induces Autophagy inhibition .
    4E1RCat 17d
  • HY-183867
    ATG5 PPI-IN-6

    		Autophagy Others
    ATG5 PPI-IN-6 (Compound 17a) is an inhibitor of ATG5 interactions with other proteins, with an IC50 value of 26.92 μM against ATG5-ATG16L1 and 16.34 μM against ATG5-TECAIR. ATG5 PPI-IN-6 inhibits Autophagy in cells .
    ATG5 PPI-IN-6
  • HY-183838
    Autophagy-IN-11

    		Autophagy Cancer
    Autophagy-IN-11 is an ATG5-targeting autophage inhibitor. Autophagy-IN-11 disrupts protein-protein interactions between ATG5 and ATG16L1, and between ATG5 and TECAIR. Autophagy-IN-11 can be used for cancer research .
    Autophagy-IN-11
  • HY-183807
    T1742

    		Autophagy Cancer
    T1742 is an autophagy inhibitor targeting ATG5. T1742 blocks and disrupts protein-protein interactions between ATG5 and ATG16L1, and between ATG5 and TECAIR.T 1742 inhibits autophagy in living cells via reduced autophagosome formation and downregulated ATG8-PE conjugation. T1742 can be used to study autophagy mechanisms .
    T1742
  • HY-183738
    4E1RCat 27d

    		Others Others
    4E1RCat 27d has a core structure of (E)-3-(2-furanylmethylene)-2-pyrrolidone. 4E1RCat 27d is an analog of 4E1rcat (HY-14427) .
    4E1RCat 27d
  • HY-183732
    ATG5 PPI-IN-2

    		Autophagy Others
    ATG5 PPI-IN-2 (Compound 12f) is a selective inhibitor of ATG5-TECAIR protein-protein interaction, with a IC50 of 19.16 μM. ATG5 PPI-IN-2 also acts as an Autophagy inhibitor .
    ATG5 PPI-IN-2
  • HY-183833
    Autophagy-IN-9

    		Autophagy Infection
    Autophagy-IN-9 is a ATG5 inhibitor with an IC50 of 21.29 μM against ATG5-TECAIR. Autophagy-IN-9 blocks the binding of ATG5 to the hot-spot amino acid residues of TECAIR protein, disrupts the assembly of ATG5-related ternary complexes, inhibits autophagosome formation, and thereby downregulates cellular autophagy levels. Autophagy-IN-9 can be used in autophagy-related research, such as studies on infection .
    Autophagy-IN-9
  • HY-183848
    ATG5-TECAIR-IN-3

    		Autophagy Cancer
    ATG5-TECAIR-IN-3 is an ATG5-targeting autophagy inhibitor. ATG5-TECAIR-IN-3 exhibits weak autophagy inhibitory activity. ATG5-TECAIR-IN-3 could be used in cancer-related research .
    ATG5-TECAIR-IN-3
  • HY-183737
    ATG5/TECAIR-IN-1

    		Autophagy Infection Cancer
    ATG5/TECAIR-IN-1 is a ATG5-TECAIR interaction inhibitor with an IC50 of 20.79 μM. ATG5/TECAIR-IN-1 inhibits autophagy. TG5/TECAIR-IN-1 is applicable to research on modulating protein-protein interactions to intervene in autophagy-related diseases, such as infectious diseases and cancers .
    ATG5/TECAIR-IN-1

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