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Cat. No.: HY-183833

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Autophagy-IN-9

Autophagy-IN-9 is a ATG5 inhibitor with an IC₅₀ of 21.29 μM against ATG5-TECAIR. Autophagy-IN-9 blocks the binding of ATG5 to the hot-spot amino acid residues of TECAIR protein, disrupts the assembly of ATG5-related ternary complexes, inhibits autophagosome formation, and thereby downregulates cellular autophagy levels. Autophagy-IN-9 can be used in autophagy-related research, such as studies on infection.

For research use only. We do not sell to patients.

CAS No.: 2841473-77-4
Formula: C₂₉H₂₀N₂O₆
Molecular Weight:492.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Autophagy-IN-9 Chemical Structure

CAS No.: 2841473-77-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

Autophagy-IN-9 (compound 12b) (20 μM; 6 h) inhibits autophagy in COS-7 cells, reducing autophagy incidence to 8.10%^[1].
Autophagy-IN-9 selectively inhibits the ATG5-TECAIR protein-protein interaction in vitro with an IC₅₀ of 21.29 μM, but does not inhibit ATG5-ATG16L1 interactions at concentrations up to 33 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Autophagy Assay^[1]

Cell Line:

COS-7 cells
Concentration:

20 μM
Incubation Time:

6 h
Result:

Reduced autophagy incidence in COS-7 cells to 8.10%.

Chemical Information

CAS No. 2841473-77-4
Molecular Weight 492.48
Formula C₂₉H₂₀N₂O₆
SMILES

O=C(N(C(C1=CC=CC=C1)=C/2)CC3=CC(C(O)=O)=CC=C3)C2=C\C4=CC=C(C5=CC=C(C=C5)[N+]([O-])=O)O4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xiang H, et al. Discovery of Small-Molecule Autophagy Inhibitors by Disrupting the Protein–Protein Interactions Involving Autophagy-Related 5. J Med Chem. 2023 Feb 7;66(4):2457-2476.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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