2841473-77-4
Chemical Structure
Autophagy-IN-9
- CAS No.: 2841473-77-4
- Formula:C29H20N2O6
- Molecular Weight:492.48
InChIKey: IVCSWFQGXLHGKI-XQNSMLJCSA-N
SMILES: O=C(N(C(C1=CC=CC=C1)=C/2)CC3=CC(C(O)=O)=CC=C3)C2=C\C4=CC=C(C5=CC=C(C=C5)[N+]([O-])=O)O4
Biological Activity: Autophagy-IN-9 is a ATG5 inhibitor with an IC50 of 21.29 μM against ATG5-TECAIR. Autophagy-IN-9 blocks the binding of ATG5 to the hot-spot amino acid residues of TECAIR protein, disrupts the assembly of ATG5-related ternary complexes, inhibits autophagosome formation, and thereby downregulates cellular autophagy levels. Autophagy-IN-9 can be used in autophagy-related research, such as studies on infection[1].
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Autophagy-IN-9 | Autophagy-IN-9 is a ATG5 inhibitor with an IC50 of 21.29 μM against ATG5-TECAIR. Autophagy-IN-9 blocks the binding of ATG5 to the hot-spot amino acid residues of TECAIR protein, disrupts the assembly of ATG5-related ternary complexes, inhibits autophagosome formation, and thereby downregulates cellular autophagy levels. Autophagy-IN-9 can be used in autophagy-related research, such as studies on infection. | |||||||||||||||||||||
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Keywords
