2. Autophagy
  3. Autophagy
  4. ATG5/TECAIR-IN-1

ATG5/TECAIR-IN-1 is a ATG5-TECAIR interaction inhibitor with an IC50 of 20.79 μM. ATG5/TECAIR-IN-1 inhibits autophagy. TG5/TECAIR-IN-1 is applicable to research on modulating protein-protein interactions to intervene in autophagy-related diseases, such as infectious diseases and cancers.

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ATG5/TECAIR-IN-1

ATG5/TECAIR-IN-1 Chemical Structure

CAS No. : 2841473-83-2

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ATG5/TECAIR-IN-1 Related Antibodies

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Description

ATG5/TECAIR-IN-1 is a ATG5-TECAIR interaction inhibitor with an IC50 of 20.79 μM. ATG5/TECAIR-IN-1 inhibits autophagy. TG5/TECAIR-IN-1 is applicable to research on modulating protein-protein interactions to intervene in autophagy-related diseases, such as infectious diseases and cancers[1].

In Vitro

ATG5/TECAIR-IN-1 (Compound 12e) inhibits the ATG5-TECAIR interaction with an IC50 of 20.79 μM, but does not inhibit the ATG5-ATG16L1 interaction in in vitro HTRF binding assays[1].
ATG5/TECAIR-IN-1 (20 μM; 6 h) inhibits autophagy in COS-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ATG5/TECAIR-IN-1 Related Antibodies

Cell Autophagy Assay[1]

Cell Line: COS-7 cells
Concentration: 20 μM
Incubation Time: 6 h
Result: Reduced autophagy incidence to 5.30% compared to the positive control-induced high autophagy levels.
Molecular Weight

444.44

Formula

C25H20N2O6
CAS No.
SMILES

OC(CCCN1C(C2=CC=CC=C2)=C/C(C1=O)=C\C3=CC=C(C4=CC=C(C=C4)[N+]([O-])=O)O3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ATG5/TECAIR-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATG5/TECAIR-IN-12841473-83-2Autophagyautophagy inhibitorATG16L1protein-protein interactionsautophagosome formationLC3-IICOS-7 cellsATG5TECAIRInhibitorinhibitorinhibit

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