IM | MedChemExpress (MCE) Life Science Reagents

By Targets:	ADC Cytotoxin (3) ADC Linker (1) Amino Acid Derivatives (1) AMPK (2) Antibiotic (1) Apoptosis (2) Bacterial (3) Bcr-Abl (1) Cytochrome P450 (1) Drug-Linker Conjugates for ADC (1) Ferroptosis (2) GSK-3 (1) Keap1-Nrf2 (1) Microtubule/Tubulin (3) Mitochondrial Metabolism (2) nAChR (1) Necroptosis (1) Neurokinin Receptor (1) Oxidative Phosphorylation (2) Parasite (1) Potassium Channel (2) PPAR (1) TRP Channel (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108351

IM-54	Necroptosis	Cardiovascular Disease
IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H₂O₂-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death .

HY-12292

IM-12

5 Publications Verification

GSK-3 Cancer

IM-12 is an inhibitor of GSK-3β, with an IC₅₀ of 53 nM, and also enhances Wnt signalling.
HY-160157

IM-2

Drug-Linker Conjugates for ADC Cancer

IM-2 is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
HY-138201

IM-93

Ferroptosis Cardiovascular Disease

IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 µM for cell death inhibition .
HY-P5715

Im6

Bacterial Infection

Im6 is an antimicrobial peptide. Im6 is active against S. aureus and B.subtilis (Gram-positive bacterial) .

IM-12 5 Publications Verification	GSK-3	Cancer
IM-12 is an inhibitor of GSK-3β, with an IC₅₀ of 53 nM, and also enhances Wnt signalling.

IM-2	Drug-Linker Conjugates for ADC	Cancer
IM-2 is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

IM-93	Ferroptosis	Cardiovascular Disease
IM-93 inhibits ferroptosis and NETosis with an IC< sub>50 of 0.45 µM for cell death inhibition .

Im6	Bacterial	Infection
Im6 is an antimicrobial peptide. Im6 is active against S. aureus and B.subtilis (Gram-positive bacterial) .

HY-125283

IM176OUT05	Mitochondrial Metabolism	Metabolic Disease
IM176OUT05 is a high solubility biguanide. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC₅₀ of 3.2 μM .

HY-P5687

Im5	Bacterial	Infection
Im5, an antimicrobial peptide, has antibacterial (MIC: 10, 2.5-5, 0.5-1 μM for E. coli, S. aureus, B. subtilis respectively) and hemolytic activity (EC₅₀: 28 μM) .

HY-136093

Lixumistat hydrochloride HL271; IM156 hydrochloride; HL156A hydrochloride	Oxidative Phosphorylation AMPK	Neurological Disease Cancer
Lixumistat (HL271) hydrochloride (IM156 hydrochloride; HL156A hydrochloride), a chemical derivative of Metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. Lixumistat hydrochloride attenuates aging-associated cognitive impairment in animal model . Lixumistat hydrochloride is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors .

HY-136093A

Lixumistat acetate IM156; HL156A; HL271 acetate	Oxidative Phosphorylation AMPK	Neurological Disease Cancer
Lixumistat (IM156; HL156A; HL271) acetate, a chemical derivative of Metformin (HY-B0627), is a potent and orally active AMPK activator that increases AMPK phosphorylation. Lixumistat (acetate) attenuates aging-associated cognitive impairment in animal model . Lixumistat (acetate) is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors .

HY-136093B

Lixumistat IM156 free base; HL156A free base; HL271 free base	Mitochondrial Metabolism	Cancer
Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat also suppresses B-cell activation to alleviate systemic lupus erythematosus .

HY-130959

Tubulysin IM-2	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-2 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.

HY-130960

Tubulysin IM-3	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-3 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis.

HY-130958

Tubulysin IM-1	ADC Cytotoxin Microtubule/Tubulin	Cancer
Tubulysin IM-1 is a microtubule/Tubulin inhibitor that can act as an ADC cytotoxin (ADC Cytotoxin) and an anti-microtubule toxin (anti-microtubule toxins). Used for ADC synthesis .

HY-135953

CDDO-3P-Im	Apoptosis	Cancer
CDDO-3P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-3P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model . CDDO-3P-Im is a orally active necroptosis inhibitor that can be used for the research of ischemia/reperfusion (I/R) .

HY-126379

CDDO-2P-Im	Apoptosis	Cancer
CDDO-2P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-2P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model .

HY-P1270

α-Conotoxin Im-I	nAChR	Neurological Disease
α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR .

HY-160577

DOG-IM4	Others	Others
DOG-IM4 can be used to synthesize nanoparticles to deliver antigen-encoding nucleic acids. It could be used to try to target autoimmune diseases, rare blood or metabolic diseases, allergies, cancer or infectious diseases .

HY-W142171

Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester

Amino Acid Derivatives Others

Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester is a histidine derivative .

Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester	Amino Acid Derivatives	Others
Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester is a histidine derivative .

HY-15725

CDDO-Im Maximum Cited Publications 7 Publications Verification RTA-403; TP-235; CDDO-IMidazolide	Keap1-Nrf2 PPAR Ferroptosis	Cancer
CDDO-Im (RTA-403) is an activator of Nrf2 and PPAR, with K_is of 232 and 344 nM for PPARα and PPARγ .

HY-W020468

Linopirdine 1 Publications Verification DuP 996	Potassium Channel TRP Channel	Neurological Disease
Linopirdine (DuP 996) is an orally active, selective M-type K ⁺ current (IM; Kv7; KCNQ Channels) inhibitor with an IC₅₀ of 2.4 μM. Linopirdine is a TRPV1 agonist. Linopirdine, a putative cognition enhancing agent, increases acetylcholine release in rat brain tissue .

HY-120009

Showdomycin

Bacterial Antibiotic Infection

Showdomycin is an antibiotic produced by IM-2-induced in Streptomyces .
HY-160714

Fmoc-Ala-Ala-Ala-amide-C-O-C-COOH

ADC Linker Cancer

Fmoc-Ala-Ala-Ala-amide-C-O-C-COOH (Compound IM-3) is a cleavable ADC linker .

Showdomycin	Bacterial Antibiotic	Infection
Showdomycin is an antibiotic produced by IM-2-induced in Streptomyces .

Fmoc-Ala-Ala-Ala-amide-C-O-C-COOH	ADC Linker	Cancer
Fmoc-Ala-Ala-Ala-amide-C-O-C-COOH (Compound IM-3) is a cleavable ADC linker .

HY-10049A

CP 122721 hydrochloride	Neurokinin Receptor	Neurological Disease
CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC₅₀ of 9.8 for human NK1 receptor expressed in IM-9 cells. CP 122721 hydrochloride exhibits anxiolytic and antidepressant-like effects .

HY-101985

BV02 1 Publications Verification	Bcr-Abl	Cancer
BV02 is a potent 4-3-3 PPI (14-3-3 protein–protein interaction) inhibitor. BV02 shows cytotoxicity for hematopoietic cells expressing the IM (imatinib mesylate)-sensitive wild type Bcr-Abl and the IM-resistant T315I mutation. BV02 has the potential for the research of chronic myeloid leukemia .

HY-145786

Abiraterone decanoate	Cytochrome P450	Cancer
Abiraterone decanoate is a potent Abiraterone proagent. Abiraterone decanoate provide a controlled release of Abiraterone and long-acting CYP17 inhibition with intramuscular (IM) delivery .

HY-134559

TKIM

Potassium Channel Neurological Disease

TKIM is a TREK-1 channel inhibitor with an IC₅₀ of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1 .

TKIM	Potassium Channel	Neurological Disease
TKIM is a TREK-1 channel inhibitor with an IC₅₀ of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1 .

HY-149697

Insecticidal agent 6	Parasite	Others
Insecticidal agent 6 (Compound Im) is an insect ryanodine receptors (RyRs) inhibitor, with an EC₅₀ value of 0.6308 µM against S. frugiperda RyRs. Insecticidal agent 6 has excellent insecticidal activity against lepidopteran pests and can be used for research on pests and diseases .

Cat. No.	Product Name	Target	Research Area

HY-P5715

Im6

Bacterial Infection

Im6 is an antimicrobial peptide. Im6 is active against S. aureus and B.subtilis (Gram-positive bacterial) .

Im6	Bacterial	Infection
Im6 is an antimicrobial peptide. Im6 is active against S. aureus and B.subtilis (Gram-positive bacterial) .

HY-P5687

Im5	Bacterial	Infection
Im5, an antimicrobial peptide, has antibacterial (MIC: 10, 2.5-5, 0.5-1 μM for E. coli, S. aureus, B. subtilis respectively) and hemolytic activity (EC₅₀: 28 μM) .

HY-P1270

α-Conotoxin Im-I	nAChR	Neurological Disease
α-Conotoxin Im-I is a selective α7/α9 nAChR antagonist, blocking α7 nicotinic receptors with the highest apparent affinity, while having an 8-fold lower affinity for homomeric α9 nicotinic receptors. α-Conotoxin Im-I is toxic and induces seizures in rodents. α-Conotoxin Im-I is a tool for studying neuronal nAChR .

HY-W142171

Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester

Amino Acid Derivatives Others

Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester is a histidine derivative .

Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester	Amino Acid Derivatives	Others
Nα-Fmoc-N(im)-trityl-L-histidine pentafluorophenyl ester is a histidine derivative .

Cat. No.	Product Name	Target	Research Area

HY-P99126

Anti-Mouse CD44 Antibody (IM7)

Inhibitory Antibodies Inflammation/Immunology

Anti-Mouse CD44 Antibody is an anti-mouse CD44 IgG2b antibody inhibitor derived from host Rat.

Anti-Mouse CD44 Antibody (IM7)	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse CD44 Antibody is an anti-mouse CD44 IgG2b antibody inhibitor derived from host Rat.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-120009

Showdomycin	Structural Classification Animals Antibiotics Source classification Other Antibiotics	Bacterial Antibiotic
Showdomycin is an antibiotic produced by IM-2-induced in Streptomyces .

Species:	Human (3) Mouse (3)
Tag:	His (1) Tag Free (5)
Source:	CHO (3) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P7085

	M-CSF Protein, Mouse Maximum Cited Publications 26 Publications Verification rMuM-CSF; CSF-1; MGI-IM	Mouse	E. coli
	M-CSF Protein, Mouse is a pro-inflammatory cytokine, binds to its receptor CSF1R, and is involved in the development and proliferation of cells of the monocyte/macrophage lineage and participates in the induction of osteoclasts which are important in the destruction of bone and cartilage and in the periarticular osteoporotic changes.

HY-P7050

	M-CSF Protein, Human 4 Publications Verification rHuM-CSF; CSF-1; MGI-IM	Human	E. coli
	M-CSF Protein, Human is a hematopoietic growth factor with various glycosylation sites, affects survival and function of the tissue macrophages, and possesses antitumor activity.

HY-P7050A

	M-CSF Protein, Human (CHO) 5 Publications Verification rHuM-CSF; CSF-1; MGI-IM	Human	CHO
	M-CSF Protein, Human (CHO) is a hematopoietic growth factor with various glycosylation sites, affects survival and function of the tissue macrophages, and possesses antitumor activity.

HY-P7085A

	M-CSF Protein, Mouse (CHO) 4 Publications Verification rMuM-CSF; CSF-1; MGI-IM	Mouse	CHO
	M-CSF Protein, Mouse (CHO) is a pro-inflammatory cytokine, binds to its receptor CSF1R, and is involved in the development and proliferation of cells of the monocyte/macrophage lineage and participates in the induction of osteoclasts which are important in the destruction of bone and cartilage and in the periarticular osteoporotic changes.

HY-P700222AF

	Animal-Free M-CSF Protein, Mouse (His) rMuM-CSF; CSF-1; MGI-IM	Mouse	E. coli
	The M-CSF protein is a key orchestrator in regulating the survival, proliferation, and differentiation of hematopoietic precursor cells, particularly mononuclear phagocytes, including macrophages and monocytes. It actively promotes the release of pro-inflammatory chemokines, thereby playing a key role in innate immunity and inflammatory processes. Animal-Free M-CSF Protein, Mouse (His) is the recombinant mouse-derived animal-FreeM-CSF protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free M-CSF Protein, Mouse (His) is 155 a.a., with molecular weight of ~19.02 kDa.

HY-P701101

	M-CSF Protein, Human (CHO,Tag Free) rHuM-CSF; CSF-1; MGI-IM	Human	CHO
	M-CSF Protein, Human (CHO) is a hematopoietic growth factor with various glycosylation sites, affects survival and function of the tissue macrophages, and possesses antitumor activity.


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