2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. Lixumistat

Lixumistat  (Synonyms: IM156 free base; HL156A free base; HL271 free base)

Cat. No.: HY-136093B
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Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat also suppresses B-cell activation to alleviate systemic lupus erythematosus.

For research use only. We do not sell to patients.

Lixumistat Chemical Structure

Lixumistat Chemical Structure

CAS No. : 1422365-93-2

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Description

Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat also suppresses B-cell activation to alleviate systemic lupus erythematosus[1][5].

Molecular Weight

315.29

Formula

C13H16F3N5O
CAS No.
SMILES

N=C(N1CCCC1)NC(NC2=CC=C(OC(F)(F)F)C=C2)=N
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Room temperature in continental US; may vary elsewhere.
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Lixumistat Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lixumistat1422365-93-2IM156HL156AHL271IM 156IM-156HL 271HL-271Mitochondrial MetabolismB-cell metabolismautoimmune diseasessystemic lupus erythematosusInhibitorinhibitorinhibit

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