1. Epigenetics
    PI3K/Akt/mTOR
  2. AMPK
  3. IM156

IM156 (Synonyms: HL156A)

Cat. No.: HY-136093A Purity: 99.80%
Handling Instructions

IM156 (HL156A), a chemical derivative of metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model.

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IM156 Chemical Structure

IM156 Chemical Structure

CAS No. : 1422365-94-3

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Description

IM156 (HL156A), a chemical derivative of metformin (HY-B0627), is a potent AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model[1][2].

IC50 & Target

AMPK[1][2]

In Vitro

IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells[1].
IM156 does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1)[1].

Western Blot Analysis[1]

Cell Line: NIH3T3 cells
Concentration: 0.31 μM, 0.62 μM, 1.25 μM, 2.5 μM, 5 μM, 10 μM
Incubation Time: 4 hours
Result: Significantly increased the AMPK phosphorylation rate.
In Vivo

IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity[1].
IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety [2].
IM156 significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory[2].
IM156 significantly increases AMPK activation in the hippocampus of aged mice[2].

Animal Model: C57BL/6J mice (young group/12~16 weeks, old groups/20~22 months)[2]
Dosage: 50 mg/kg
Administration: Oral administration (drinking water), for 2 months
Result: Attenuated age-related cognitive decline.
Molecular Weight

375.35

Formula

C₁₅H₂₀F₃N₅O₃

CAS No.

1422365-94-3

SMILES

N=C(N1CCCC1)NC(NC2=CC=C(OC(F)(F)F)C=C2)=N.CC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (266.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6642 mL 13.3209 mL 26.6418 mL
5 mM 0.5328 mL 2.6642 mL 5.3284 mL
10 mM 0.2664 mL 1.3321 mL 2.6642 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

IM156HL156AIM 156IM-156AMPKAMP-activated protein kinasemetformindementiaADcognitivefunctionmemoryage-relateddeclineInhibitorinhibitorinhibit

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IM156
Cat. No.:
HY-136093A
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