1422365-52-3
Chemical Structure
Lixumistat hydrochloride
Synonym(s): HL271; IM156 hydrochloride; HL156A hydrochloride
- CAS No.: 1422365-52-3
- Formula:C13H17ClF3N5O
- Molecular Weight:351.76
IUPAC Name: N-(N-(4-(trifluoromethoxy)phenyl)carbamimidoyl)pyrrolidine-1-carboximidamide hydrochloride
InChIKey: FSEAYPJRYNBFTN-UHFFFAOYSA-N
SMILES: N=C(N1CCCC1)NC(NC2=CC=C(OC(F)(F)F)C=C2)=N.[H]Cl
Biological Activity: Lixumistat (IM156) hydrochloride is a potent and orally active AMPK activator and OXPHOS inhibitor. Lixumistat hydrochloride strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat hydrochloride exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis[1][2][3].
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Lixumistat hydrochloride | 99.25% | Lixumistat (IM156) hydrochloride is a potent and orally active AMPK activator and OXPHOS inhibitor. Lixumistat hydrochloride strongly activates AMPK, while it lacks the systemic metabolic regulatory effects of classic metformin, such as hypoglycemic and weight-lowering activities. Lixumistat hydrochloride exhibits significant therapeutic effects on cognitive decline associated with brain aging and pulmonary fibrosis. | ||||||||||||||||||||
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Similarity Score 0.98
HY-136093BLixumistat -
Similarity Score 0.92
HY-136093ALixumistat acetate -
Similarity Score 0.66
HY-WAA02481-(4-(Trifluoromethoxy)phenyl)piperazine hydrochloride -
Similarity Score 0.64
HY-130723AMPK activator 2 -
Similarity Score 0.61
HY-101294RTPPU (Standard) -
Similarity Score 0.61
HY-B0806AProguanil hydrochloride -
Similarity Score 0.61
HY-100410FCCP -
Similarity Score 0.60
HY-B0806Proguanil -
Similarity Score 0.60
HY-B2049Triflumuron -
Explore the MedChemAI to find more analogs
References
- [1]. Bang E, et al. The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline. Exp Neurobiol. 2018;27(1):45-56. [Content Brief]
- [2]. Willette RN, et al. Modulation of Oxidative Phosphorylation with IM156 Attenuates Mitochondrial Metabolic Reprogramming and Inhibits Pulmonary Fibrosis. J Pharmacol Exp Ther. 2021;379(3):290-300. [Content Brief]
- [3]. Row H, et al. HL271, a novel chemical compound derived from metformin, differs from metformin in its effects on the circadian clock and metabolism. Biochem Biophys Res Commun. 2016;469(3):783-789. [Content Brief]
