2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. IM176OUT05

IM176OUT05 is a high solubility biguanide. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM.

For research use only. We do not sell to patients.

IM176OUT05 Chemical Structure

IM176OUT05 Chemical Structure

CAS No. : 1643659-96-4

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5 mg USD 230 In-stock
10 mg USD 380 In-stock
25 mg USD 760 In-stock
50 mg USD 1200 In-stock
100 mg USD 1900 In-stock
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Based on 1 publication(s) in Google Scholar

IM176OUT05 Related Antibodies

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Description

IM176OUT05 is a high solubility biguanide. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM[1].

In Vitro

IM176OUT05 (0.1-10 μM; 24 hour) inhibits mitochondrial function and reduces the oxygen consumption rate (OCR) as a surrogate of mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM[1].
IM176OUT05 (10 μM; 6 days) improves the acquisition and maintenance of stem cell pluripotency of mouse and human induced pluripotent stem cells (iPSCs)[1].
IM176OUT05 (10 and 100 nM) facilitates the transition of glycolytic metabolism and induces of the expression of glycolysis-related genes and ETC complex enzymes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IM176OUT05 Related Antibodies
In Vivo

IM176OUT05 (200 μL, 1%; apply to the depilated area, once daily) promotes hair regrowth in mice by stimulating the progression of the hair follicle cycle to the anagen phase and increasing the hair follicle number[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 7-week-old C57BL/6 mice[1]
Dosage: 200 μL, 1%
Administration: Apply to the depilated area; 200 μL, 1%, once daily
Result: Strongly promoted the hair regrowth, especially in female mice.
Molecular Weight

255.75

Formula

C11H18ClN5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC(NC(NCCC1=CC=CC=C1C)=N)=N.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (488.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9101 mL 19.5503 mL 39.1007 mL
5 mM 0.7820 mL 3.9101 mL 7.8201 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9101 mL 19.5503 mL 39.1007 mL 97.7517 mL
5 mM 0.7820 mL 3.9101 mL 7.8201 mL 19.5503 mL
10 mM 0.3910 mL 1.9550 mL 3.9101 mL 9.7752 mL
15 mM 0.2607 mL 1.3034 mL 2.6067 mL 6.5168 mL
20 mM 0.1955 mL 0.9775 mL 1.9550 mL 4.8876 mL
25 mM 0.1564 mL 0.7820 mL 1.5640 mL 3.9101 mL
30 mM 0.1303 mL 0.6517 mL 1.3034 mL 3.2584 mL
40 mM 0.0978 mL 0.4888 mL 0.9775 mL 2.4438 mL
50 mM 0.0782 mL 0.3910 mL 0.7820 mL 1.9550 mL
60 mM 0.0652 mL 0.3258 mL 0.6517 mL 1.6292 mL
80 mM 0.0489 mL 0.2444 mL 0.4888 mL 1.2219 mL
100 mM 0.0391 mL 0.1955 mL 0.3910 mL 0.9775 mL
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IM176OUT05 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IM176OUT051643659-96-4Mitochondrial Metabolismhigh solubilitybiguanidesmall moleculeETCOCRmitochondrial functioniPSCInhibitorinhibitorinhibit

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