CP 122721 hydrochloride
CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC50 of 9.8 for human NK1 receptor expressed in IM-9 cells. CP 122721 hydrochloride exhibits anxiolytic and antidepressant-like effects.
For research use only. We do not sell to patients.
- CAS No.: 145877-52-7
- Formula: C20H25Cl2F3N2O2
- Molecular Weight:453.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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human NK1 9.8 (pIC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| IM-9 | IC50 |
0.012 nM
Compound: 55, CP-122721
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Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
Displacement of [125I]BH-SP from NK1 receptor in human IM9 cells after 30 mins by scintillation counting
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[PMID: 21944973] |
Chemical Information
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CAS No. 145877-52-7
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Molecular Weight 453.33
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Formula C20H25Cl2F3N2O2
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SMILES
COC1=C(C=C(C=C1)OC(F)(F)F)CN[C@H]2CCCN[C@H]2C3=CC=CC=C3.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. McLean S, et, al. Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor. J Pharmacol Exp Ther. 1996 May;277(2):900-8. [Content Brief]
[2]. Kamel A, et, al. Metabolism and excretion of CP-122,721, a non-peptide antagonist of the neurokinin NK1 receptor, in dogs: identification of the novel cleaved product 5-trifluoromethoxy salicylic acid in plasma. Xenobiotica. 2007 May;37(5):559-78. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP 122721 hydrochloride Related Classifications
HY-10049A Related Classifications
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