145877-52-7
145877-52-7
Chemical Structure
CP 122721 hydrochloride
- CAS No.: 145877-52-7
- Formula:C20H25Cl2F3N2O2
- Molecular Weight:453.33
IUPAC Name: (2S,3S)-N-(2-methoxy-5-(trifluoromethoxy)benzyl)-2-phenylpiperidin-3-amine dihydrochloride
InChIKey: AVTRGAPFNJEOTQ-FFUVTKDNSA-N
SMILES: COC1=C(C=C(C=C1)OC(F)(F)F)CN[C@H]2CCCN[C@H]2C3=CC=CC=C3.Cl.Cl
Biological Activity: CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC50 of 9.8 for human NK1 receptor expressed in IM-9 cells. CP 122721 hydrochloride exhibits anxiolytic and antidepressant-like effects[1][2].
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CP 122721 hydrochloride | CP 122721 hydrochloride is a potent, non-peptide and selective nonpeptide neurokinin NK1 antagonist, with a pIC50 of 9.8 for human NK1 receptor expressed in IM-9 cells. CP 122721 hydrochloride exhibits anxiolytic and antidepressant-like effects. | |||||||||||||||||||||
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References
- [1]. McLean S, et, al. Characterization of CP-122,721; a nonpeptide antagonist of the neurokinin NK1 receptor. J Pharmacol Exp Ther. 1996 May;277(2):900-8. [Content Brief]
- [2]. Kamel A, et, al. Metabolism and excretion of CP-122,721, a non-peptide antagonist of the neurokinin NK1 receptor, in dogs: identification of the novel cleaved product 5-trifluoromethoxy salicylic acid in plasma. Xenobiotica. 2007 May;37(5):559-78. [Content Brief]
Keywords
