2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. IM-2

IM-2 is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

IM-2 Chemical Structure

IM-2 Chemical Structure

CAS No. : 2813269-89-3

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IM-2 Related Antibodies

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Description

IM-2 is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Molecular Weight

673.69

Formula

C29H35N7O10S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(COCNC(CNC([C@@H](NC(CNC(CNC(CCCC#CC1=CN=C(S(C)(=O)=O)N=C1)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (148.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4844 mL 7.4218 mL 14.8436 mL
5 mM 0.2969 mL 1.4844 mL 2.9687 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4844 mL 7.4218 mL 14.8436 mL 37.1091 mL
5 mM 0.2969 mL 1.4844 mL 2.9687 mL 7.4218 mL
10 mM 0.1484 mL 0.7422 mL 1.4844 mL 3.7109 mL
15 mM 0.0990 mL 0.4948 mL 0.9896 mL 2.4739 mL
20 mM 0.0742 mL 0.3711 mL 0.7422 mL 1.8555 mL
25 mM 0.0594 mL 0.2969 mL 0.5937 mL 1.4844 mL
30 mM 0.0495 mL 0.2474 mL 0.4948 mL 1.2370 mL
40 mM 0.0371 mL 0.1855 mL 0.3711 mL 0.9277 mL
50 mM 0.0297 mL 0.1484 mL 0.2969 mL 0.7422 mL
60 mM 0.0247 mL 0.1237 mL 0.2474 mL 0.6185 mL
80 mM 0.0186 mL 0.0928 mL 0.1855 mL 0.4639 mL
100 mM 0.0148 mL 0.0742 mL 0.1484 mL 0.3711 mL
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IM-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IM-22813269-89-3IM2IM 2Drug-Linker Conjugates for ADCADC LinkerInhibitorinhibitorinhibit

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