1. Apoptosis
  2. Apoptosis
  3. CDDO-2P-Im

CDDO-2P-Im 

Cat. No.: HY-126379
Handling Instructions

CDDO-2P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-2P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model.

For research use only. We do not sell to patients.

CDDO-2P-Im Chemical Structure

CDDO-2P-Im Chemical Structure

CAS No. : 1883650-96-1

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Description

CDDO-2P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-2P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model[1].

In Vitro

CDDO-2P-Im (100 nM; 4 days) induces differentiation of U937 cells at 100 nM[1].
CDDO-2P-Im suppresses NO production in RAW264.7 cells with an IC50 of 5.8 nM[1].

Apoptosis Analysis[1]

Cell Line: U937 cells
Concentration: 30 nM, 100 nM
Incubation Time: 4 days
Result: Induced differentiation of U937 cells at 100 nM.
In Vivo

CDDO-2P-Im is more stable than CDDO-Im in pharmacokinetic studies[1].
CDDO-2P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo[1].
CDDO-2P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice[1].

Animal Model: Seven week-old female A/J mice[1]
Dosage: 50 mg/kg, 200 mg/kg
Administration: Diet; for 16 weeks
Result: Decreased the number, the size and the severity of tumors.
Molecular Weight

618.81

Formula

C₃₉H₄₆N₄O₃

CAS No.

1883650-96-1

SMILES

CC(C)([[email protected]](CC[[email protected]@]([[email protected]@]1(CC[[email protected]]2(CCC(C)(C[[email protected]]2([[email protected]]13[H])[H])C)C(N4C=C(C5=NC=CC=C5)N=C4)=O)C)6C)7[H])C(C(C#N)=C[[email protected]]7(C)C6=CC3=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CDDO-2P-ImApoptosisCDDO-ImidazolidechemopreventionchemopreventivelungcancerInhibitorinhibitorinhibit

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CDDO-2P-Im
Cat. No.:
HY-126379
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