2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. TKIM

TKIM is a TREK-1 channel inhibitor with an IC50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1.

For research use only. We do not sell to patients.

TKIM Chemical Structure

TKIM Chemical Structure

CAS No. : 326921-25-9

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5 mg USD 290 In-stock
10 mg USD 450 In-stock
25 mg USD 790 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TKIM is a TREK-1 channel inhibitor with an IC50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1[1].

Molecular Weight

371.84

Formula

C18H14ClN3O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NNC(CSC1=NC2=CC=CC=C2C=C1)=O)C3=CC=C(Cl)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (672.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6893 mL 13.4466 mL 26.8933 mL
5 mM 0.5379 mL 2.6893 mL 5.3787 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6893 mL 13.4466 mL 26.8933 mL 67.2332 mL
5 mM 0.5379 mL 2.6893 mL 5.3787 mL 13.4466 mL
10 mM 0.2689 mL 1.3447 mL 2.6893 mL 6.7233 mL
15 mM 0.1793 mL 0.8964 mL 1.7929 mL 4.4822 mL
20 mM 0.1345 mL 0.6723 mL 1.3447 mL 3.3617 mL
25 mM 0.1076 mL 0.5379 mL 1.0757 mL 2.6893 mL
30 mM 0.0896 mL 0.4482 mL 0.8964 mL 2.2411 mL
40 mM 0.0672 mL 0.3362 mL 0.6723 mL 1.6808 mL
50 mM 0.0538 mL 0.2689 mL 0.5379 mL 1.3447 mL
60 mM 0.0448 mL 0.2241 mL 0.4482 mL 1.1206 mL
80 mM 0.0336 mL 0.1681 mL 0.3362 mL 0.8404 mL
100 mM 0.0269 mL 0.1345 mL 0.2689 mL 0.6723 mL
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TKIM Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TKIM326921-25-9Potassium ChannelKcsATREK-1 channel inhibitorintermediate stateInhibitorinhibitorinhibit

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