1. Apoptosis
  2. Apoptosis
  3. CDDO-3P-Im

CDDO-3P-Im 

Cat. No.: HY-135953 Purity: 98.19%
Handling Instructions

CDDO-3P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-3P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model .

For research use only. We do not sell to patients.

CDDO-3P-Im Chemical Structure

CDDO-3P-Im Chemical Structure

CAS No. : 1883650-95-0

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 381 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

CDDO-3P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-3P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model [1].

In Vitro

CDDO-3P-Im (30-100 nM; 4 days) induces differentiation of U937 cells at 30 nM[1].
CDDO-3P-Im suppresses NO production in RAW264.7 cells with an IC50 of 4.3 nM[1].

Apoptosis Analysis[1]

Cell Line: U937 cells
Concentration: 30 nM, 100 nM
Incubation Time: 4 days
Result: Induced differentiation of U937 cells at 30 nM.
In Vivo

CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies[1].
CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo[1].
CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice[1].

Animal Model: Seven week-old female A/J mice[1]
Dosage: 50 mg/kg, 200 mg/kg
Administration: Diet; for 16 weeks
Result: Decreased the number, the size and the severity of tumors.
Molecular Weight

618.81

Formula

C₃₉H₄₆N₄O₃

CAS No.

1883650-95-0

SMILES

CC(C)([[email protected]](CC[[email protected]@]([[email protected]@]1(CC[[email protected]]2(CCC(C)(C[[email protected]]2([[email protected]]13[H])[H])C)C(N4C=C(C5=CC=CN=C5)N=C4)=O)C)6C)7[H])C(C(C#N)=C[[email protected]]7(C)C6=CC3=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (404.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6160 mL 8.0800 mL 16.1600 mL
5 mM 0.3232 mL 1.6160 mL 3.2320 mL
10 mM 0.1616 mL 0.8080 mL 1.6160 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.36 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CDDO-3P-ImApoptosisCDDO-ImidazolidechemopreventionchemopreventivelungcancerInhibitorinhibitorinhibit

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Product Name:
CDDO-3P-Im
Cat. No.:
HY-135953
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