O-methylated

By Targets:	Aldehyde Dehydrogenase (ALDH) (1) CFTR (2) COX (1) Dipeptidyl Peptidase (1) Endogenous Metabolite (3) FAK (1) MMP (1) Vasopressin Receptor (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (2) Metabolic Disease (5)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7653

Azaleatin	Dipeptidyl Peptidase	Metabolic Disease
Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity .

HY-W008794

Normetanephrine hydrochloride (±)-Normetanephrine hydrochloride; DL-Normetanephrine hydrochloride; (Rac)-Normetanephrine hydrochloride	Endogenous Metabolite	Metabolic Disease
Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE) .

HY-113299

Metanephrine

Endogenous Metabolite Cancer

Metanephrine is the O-methylated metabolite of epinephrine that can be used for the research of diagnosis of pheochromocytoma .

Metanephrine	Endogenous Metabolite	Cancer
Metanephrine is the O-methylated metabolite of epinephrine that can be used for the research of diagnosis of pheochromocytoma .

HY-W008794S

Normetanephrine-d3 hydrochloride (±)-Normetanephrine-d₃ (hydrochloride); DL-Normetanephrine-d₃ (hydrochloride); (Rac)-Normetanephrine-d₃ (hydrochloride)	Endogenous Metabolite	Metabolic Disease
Normetanephrine-d₃ (hydrochloride) is the deuterium labeled Normetanephrine hydrochloride. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE)[1].

HY-N8840

Laricitrin

Others Cancer

Laricitrin (compound 4) is an O-methylated flavonol, a type of flavonoid, that has anti-tumor effect .

Laricitrin	Others	Cancer
Laricitrin (compound 4) is an O-methylated flavonol, a type of flavonoid, that has anti-tumor effect .

HY-N2597

Prunetin	Aldehyde Dehydrogenase (ALDH)	Inflammation/Immunology
Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor .

HY-N6010

8-Hydroxybergapten	Others	Others
8-hydroxybergapten is O-methylated by cell-free extracts of Ruta cells to isopimpinellin, in reactions mediated by discrete O-methyltransferases. 8-hydroxybergapten has excellent anti-wrinkle effect .

HY-N4128

4''-methyloxy-Daidzin Daidzein 7-O-Β-D-glucoside 4''-O-methylate	Others	Inflammation/Immunology
4''-methyloxy-Daidzin (Daidzein 7-O-Β-D-glucoside 4''-O-methylate), an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities .

HY-126410

Petunidin chloride	FAK	Metabolic Disease
Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.

HY-N2459

Peonidin chloride YGM-6 chloride	COX	Cancer
Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

HY-P1108

Astressin 2B	CFTR	Others
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P1108A

Astressin 2B TFA	CFTR	Others
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P4521

*Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt*	MMP	Others
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate, and can be used to detect MMP12 enzyme activity .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

Cat. No.	Product Name	Target	Research Area

HY-P1108A

Astressin 2B TFA	CFTR	Others
Astressin 2B TFA is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B TFA antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P4756

*N-(2-Carbamoyl-ethyl)-Val-Leu-anilide*	Peptides	Others
N-(2-Carbamoyl-ethyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P1108

Astressin 2B	CFTR	Others
Astressin 2B is a potent and selective corticotropin-releasing factor receptor 2 (CRF2) antagonist, with the IC₅₀ values of 1.3 nM and > 500 nM for CRF2 and CRF1, respectively. Astressin 2B antagonizes CRF2-mediated inhibition of gastric emptying .

HY-P2592

Ro 23-7014

Peptides Others

Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

Ro 23-7014	Peptides	Others
Ro 23-7014 is an appetite suppressant. Ro 23-7014 is an analog of cholecystokinin (CCK-7) .

HY-P4521

*Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt*	MMP	Others
Ac-Pro-Leu-Gly-[(S)-2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OEt is a MMP12 substrate, and can be used to detect MMP12 enzyme activity .

HY-P3066

SKF 100398 d(CH2)5Tyr(Et)VAVP	Vasopressin Receptor	Metabolic Disease
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7653

Azaleatin	Flavonols Structural Classification Flavonoids Classification of Application Fields Carthamus tinctorius L. Source classification Phenols Polyphenols Metabolic Disease Plants Compositae Disease Research Fields	Dipeptidyl Peptidase
Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity .

HY-W008794

Normetanephrine hydrochloride (±)-Normetanephrine hydrochloride; DL-Normetanephrine hydrochloride; (Rac)-Normetanephrine hydrochloride	Classification of Application Fields Source classification Phenols Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE) .

HY-113299

Metanephrine	Structural Classification Alkaloids Monophenols Classification of Application Fields Other Alkaloids Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Metanephrine is the O-methylated metabolite of epinephrine that can be used for the research of diagnosis of pheochromocytoma .

HY-N2597

Prunetin	Structural Classification Classification of Application Fields Source classification Plants Trifolium pratense Linn. Flavonoids Leguminosae Phenols Polyphenols Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones	Aldehyde Dehydrogenase (ALDH)
Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor .

HY-N8840

Laricitrin	Structural Classification Flavonols Flavonoids Source classification Myrtaceae Plants Syzygium nervosum Candolle	Others
Laricitrin (compound 4) is an O-methylated flavonol, a type of flavonoid, that has anti-tumor effect .

HY-N6010

8-Hydroxybergapten	Monophenols Classification of Application Fields Isodon excisoides (Sun ex C. H. Hu) H. Hara Source classification Other Diseases Coumarins Phenols Phenylpropanoids Plants Umbelliferae Disease Research Fields	Others
8-hydroxybergapten is O-methylated by cell-free extracts of Ruta cells to isopimpinellin, in reactions mediated by discrete O-methyltransferases. 8-hydroxybergapten has excellent anti-wrinkle effect .

HY-N4128

4''-methyloxy-Daidzin Daidzein 7-O-Β-D-glucoside 4''-O-methylate	Flavonoids Monophenols Classification of Application Fields Leguminosae Glycine max (L.) merr Source classification Phenols Plants Disease Research Fields Inflammation/Immunology Isoflavones	Others
4''-methyloxy-Daidzin (Daidzein 7-O-Β-D-glucoside 4''-O-methylate), an isoflavone methyl-glycoside, is isolated from Cordyceps militaris grown on germinated soybeans. Isoflavones possess immunomodulating and antiallergic activities .

HY-126410

Petunidin chloride	Anthocyans Flavonoids Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Solanaceae Disease Research Fields Etunia hybrida (J. D. Hooker) Vilmorin	FAK
Petunidin chloride is an O-methylated anthocyanidin derived from delphinidin. Petunidin chloride binds with and suppresses the activity of focal adhesion kinase and to inhibit platelet-derived growth factor-induced aortic smooth muscle cell migration, which may confer a protective effect against atherosclerosis.

HY-N2459

Peonidin chloride YGM-6 chloride	Classification of Application Fields Source classification Plants Food Research Anthocyans Flavonoids Microorganisms Paeonia lactiflora Pall. Phenols Polyphenols Pigments Paeoniaceae Disease Research Fields Cancer	COX
Peonidin chloride is an O-methylated anthocyanidin that functions as a primary plant pigment, endowing purplish-red hues to flowers such as the peony, from which it takes its name, as well as berries and vegetables. Peonidin chloride exhibits chemopreventive, as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells.

Cat. No.	Product Name	Chemical Structure

HY-W008794S

Normetanephrine-d3 hydrochloride
Normetanephrine-d₃ (hydrochloride) is the deuterium labeled Normetanephrine hydrochloride. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE)[1].

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