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Results for "

SGC-7901/CDDP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (1) Akt (2) Aldose Reductase (1) Apoptosis (15) Autophagy (8) Bacterial (1) c-Met/HGFR (1) Caspase (2) DNA Alkylator/Crosslinker (4) DNA/RNA Synthesis (2) Dopamine Receptor (1) Endogenous Metabolite (1) Ferroptosis (2) Histone Demethylase (1) Isotope-Labeled Compounds (2) Lipoxygenase (1) MDM-2/p53 (1) Microtubule/Tubulin (5) Mitophagy (2) NF-κB (2) NO Synthase (1) Parasite (2) PI3K (1) Pyroptosis (2) Raf (1) Ras (1) Reactive Oxygen Species (2) ROS Kinase (1) SOD (1) STAT (1) TAM Receptor (1) TNF Receptor (1) YAP (1)
By Research Areas:	Cancer (30) Infection (3) Inflammation/Immunology (3) Neurological Disease (1)

By Targets:

5-HT Receptor (1)

Adrenergic Receptor (1)

Akt (2)

Aldose Reductase (1)

Apoptosis (15)

Autophagy (8)

Bacterial (1)

c-Met/HGFR (1)

Caspase (2)

DNA Alkylator/Crosslinker (4)

DNA/RNA Synthesis (2)

Dopamine Receptor (1)

Endogenous Metabolite (1)

Ferroptosis (2)

Histone Demethylase (1)

Isotope-Labeled Compounds (2)

Lipoxygenase (1)

MDM-2/p53 (1)

Microtubule/Tubulin (5)

Mitophagy (2)

NF-κB (2)

NO Synthase (1)

Parasite (2)

PI3K (1)

Pyroptosis (2)

Raf (1)

Ras (1)

Reactive Oxygen Species (2)

ROS Kinase (1)

SOD (1)

STAT (1)

TAM Receptor (1)

TNF Receptor (1)

YAP (1)

By Research Areas:

Cancer (30)

Infection (3)

Inflammation/Immunology (3)

Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N7980

Rubipodanone A	NF-κB	Cancer
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-W015084

β-Ionone

Apoptosis Cancer

β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .
HY-N10201

Cytoglobosin C

Endogenous Metabolite Cancer

Cytoglobosin C, a cytochalasan derivative, shows potent cytotoxicity against both SGC-7901 and A549 cell lines (IC₅₀<10 μM) .

β-Ionone	Apoptosis	Cancer
β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity .

Cytoglobosin C	Endogenous Metabolite	Cancer
Cytoglobosin C, a cytochalasan derivative, shows potent cytotoxicity against both SGC-7901 and A549 cell lines (IC₅₀<10 μM) .

HY-161351

STAT3/AKT-IN-1	Akt STAT Apoptosis	Cancer
STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells .

HY-N1841

Rocaglamide D 3'-Hydroxyrocaglamide
Rocaglamide D (3'-Hydroxyrocaglamide) (compound 1) is a lignan that can be found in Aglaia odorata. Rocaglamide D shows cytotoxicity with IC₅₀s of 0.32, 0.12, 0.25 µM for HeLa, SGC-7901, A549 cells, respectively .

HY-N9046

Citroside A	NO Synthase	Inflammation/Immunology Cancer
Citroside A is a megastigmane sesquiterpenoid with cytotoxic and anti-inflammatory activities. Citroside A displays potential effects against NO production with an IC₅₀ of 34.25 μM. Citroside A exhibits pronounced cytotoxicity against SGC-7901 and HeLa cells with IC₅₀ values of 27.52 μM and 29.51 μM, respectively .

HY-147947

Tubulin polymerization-IN-30	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-30 (compound 6e) is a potent Tubulin polymerization inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC₅₀ values of 2.16, 2.21, and 0.403 μM .

HY-155360

MY-1076	YAP Apoptosis	Cancer
MY-1076 is an inhibitor of YAP. MY-1076 induces YAP degradation and cell apoptosis. MY-1076 inhibits MGC-803, SGC-7901, HCT-116 and KYSE450 cells proliferation with IC₅₀ s of 0.019, 0.017, 0.020 and 0.044 μM, respectively .

HY-156098

c-Met-IN-19	c-Met/HGFR	Cancer
c-Met-IN-19 (Compound 21j) is a c-Met inhibitor (IC₅₀: 1.99 nM). c-Met-IN-19 shows cytotoxicity against A549, HT-29, SGC-7901, MDA-MB-231 cells with IC₅₀s of 0.25, 0.36, 0.98, 0.76 μM .

HY-146311

Tubulin polymerization-IN-16	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-16 (compound 5g) is a potent inhibitor of tubulin polymerization. Tubulin polymerization-IN-16 shows most potent against cancer cells, with IC₅₀ values of 0.084-0.221 μM. Tubulin polymerization-IN-16 potently disrupts microtubule/tubulin dynamics, induces cell cycle arrest at G2/M phase in SGC-7901 cells .

HY-W015084S

β-Ionone-13C3	Isotope-Labeled Compounds Apoptosis	Cancer
β-Ionone- ¹³C₃ is the ¹³C-labeled β-Ionone. β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity[1].

HY-W015084A

(E)-β-Ionone β-Lonone	Apoptosis	Cancer
(E)-β-Ionone is the isomer of β-Ionone (HY-W015084). β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. β-Ionone has anti-cancer activity .

HY-17394

Cisplatin Maximum Cited Publications 383 Publications Verification cis-Platinum; CDDP; cis-Diaminodichloroplatinum	DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase	Cancer
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .

HY-17394R

Cisplatin (Standard) cis-Platinum (Standard); CDDP (Standard); cis-Diaminodichloroplatinum (Standard)	DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis	Cancer
Cisplatin (Standard) is the analytical standard of Cisplatin. This product is intended for research and analytical applications. Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .

HY-17393

Carboplatin 35+ Cited Publications NSC 241240	DNA Alkylator/Crosslinker Autophagy DNA/RNA Synthesis	Cancer
Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.

HY-100690

NSC16168

NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC₅₀ value of 0.42 μM. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer .

NSC16168
NSC16168 is a specific inhibitor of ERCC1-XPF, with an IC₅₀ value of 0.42 μM. NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer .

HY-17393S

Carboplatin-d4 NSC 241240-d₄	Isotope-Labeled Compounds DNA Alkylator/Crosslinker Autophagy DNA/RNA Synthesis	Cancer
Carboplatin-d₄ is the deuterium labeled Carboplatin. Carboplatin (NSC 241240) is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death. Carboplatin (NSC 241240) is a derivative of CDDP and a potent anti-cancer agent.

HY-146080

Antitumor agent-61	Apoptosis	Cancer
Antitumor agent-61 (Compound 9b), Irinotecan (Ir) derivative, is a potential antitumor agent. Antitumor agent-61 displays potent activity with IC₅₀s of 0.92, 1.39, 1.75, 2.20, 3.05 and 3.23 μM against five human cancer cells SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549 and MG-63, respectively. Antitumor agent-61 induces SK-OV-3 cells apoptosis through mitochondrion pathways .

HY-149918

Antiproliferative agent-23	Microtubule/Tubulin Apoptosis	Cancer
Antiproliferative agent-23 is a microtubule-destabilizing agent (MDA) and efficiently disturbes the tubulin-microtubule system. Antiproliferative agent-23 induces apoptosis via a mitochondrion-dependent pathway by downregulating the Bcl-2 protein, upregulating Bax and Cyt c proteins, and activating the caspase cascade. Antiproliferative agent-23 initiates reactive oxygen species (ROS)-mediated endoplasmic reticulum stress in A549/CDDP cells (cisplatin resistant cancer cell line) via the PERK/ATF4/CHOP signaling pathway. Antiproliferative agent-23 has anti-tumor activity .

HY-15150G

Bemcentinib (GMP)

R428 (GMP); BGB324 (GMP)
TAM Receptor Cancer

Bemcentinib (R428) GMP is an orally active and selective inhibitor of Axl with an IC₅₀ of 14 nM .

Bemcentinib (GMP) R428 (GMP); BGB324 (GMP)	TAM Receptor	Cancer
Bemcentinib (R428) GMP is an orally active and selective inhibitor of Axl with an IC₅₀ of 14 nM .

HY-158156

NF-κB-IN-16	NF-κB Apoptosis	Cancer
NF-κB-IN-16 (compound 9) is a complex (Pt(IV) complex) of NF-κB inhibitor and Cisplatin (HY-17394), which has high efficacy and low toxicity in anti-tumor activity. active. NF-κB-IN-16 can cause DNA damage, induce mitochondrial dysfunction, produce reactive oxygen species, and induce apoptosis through the mitochondrial pathway and endoplasmic reticulum stress. NF-κB-IN-16 potently inhibits the NF-κB/MAPK signaling pathway and disrupts PI3K/AKT signaling. NF-κB-IN-16 also exhibits excellent in vivo antitumor efficiency and low toxicity in A549 or A549/CDDP xenograft models. .

HY-139696

AKR1B10-IN-1	Aldose Reductase	Cancer
AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC₅₀ of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells .

HY-161338

Tubulin polymerization-IN-61	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-61 (Compound 9a) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-61 destroys the microtubule skeleton, blocks the cell cycle in G2/M phase, induces Apoptosis, and inhibits cancer cell migration and colony formation. Tubulin polymerization-IN-61 shows antitumor activity in vivo against 4T1 xenograft model .

HY-N6018

Beta-Eudesmol	Caspase TNF Receptor SOD Reactive Oxygen Species	Inflammation/Immunology Cancer
Beta-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. Beta-Eudesmol is a neostigmine antagonist. Beta-Eudesmol can antagonize neostigmine-induced neuromuscular failure. Beta-Eudesmol can be used in the study of sepsis diseases. Beta-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea .

HY-146390

Antiproliferative agent-5	Autophagy Reactive Oxygen Species	Cancer
Antiproliferative agent-5 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative agent-5 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative agent-5 can be used for researching anticancer .

HY-P10090

Apoptin-derived peptide	Akt PI3K Apoptosis	Cancer
Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating PI3K/AKT/ARNT signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the PI3K/AKT pathway involved in the development of gastric cancer .

HY-13735A

Quinacrine dihydrochloride 4 Publications Verification Mepacrine dihydrochloride; SN-390 dihydrochloride	Parasite Apoptosis Autophagy Mitophagy	Infection Cancer
Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis .

HY-13735B

Quinacrine hydrochloride hydrate Mepacrine hydrochloride hydrate; SN-390 hydrochloride hydrate	Parasite Apoptosis Autophagy Mitophagy	Infection Cancer
Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis .

HY-163404

Urease-IN-13	Bacterial	Infection Inflammation/Immunology
Urease-IN-13 (compound d8) is an inhibitor of urease with an IC₅₀ value of 1.21 μM. Urease-IN-13 has been studied in the context of infectious gastritis and gastric ulcers .

HY-122928

Rosamultic acid	Apoptosis Caspase	Cancer
Rosamultic acid is an A-ring contracted triterpene, that can be isolated from the roots of Rosa rnultiflora. Rosamultic acid inhibits gastric cancer cells proliferation by inducing apoptosis mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases .

HY-155686

Tubulin polymerization-IN-44	Microtubule/Tubulin	Cancer
Tubulinpolymer-in-44 (compound 7w) is a strong and effective Tubulin inhibitor, with an IC₅₀ value of 0.21 μM. Tubulinpolymer-in-44 induces apoptosis by arresting G2/M phase, which can be used for cancer research.

HY-146432

Antitumor agent-60	Apoptosis Raf Ras ROS Kinase MDM-2/p53
Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a K_d value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model .

HY-149968

LSD1-IN-25	Histone Demethylase Apoptosis	Cancer
LSD1-IN-25 (Compound 9j) is a potent, selective and orally active LSD₁ inhibitor with an IC₅₀ of 46 nM (K_i = 30.3 nM). LSD1-IN-25 induces cancer cell apoptosis .

HY-14543

Sertindole 2 Publications Verification Lu 23-174	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy	Neurological Disease Cancer
Sertindole (Lu 23-174) is an orally active 5-HT_2A, 5-HT_2C, dopamine D₂, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells .

Bemcentinib (GMP) R428 (GMP); BGB324 (GMP)	Fluorescent Dye
Bemcentinib (R428) GMP is an orally active and selective inhibitor of Axl with an IC₅₀ of 14 nM .

Bemcentinib (GMP) R428 (GMP); BGB324 (GMP)	Biochemical Assay Reagents
Bemcentinib (R428) GMP is an orally active and selective inhibitor of Axl with an IC₅₀ of 14 nM .

Apoptin-derived peptide	Akt PI3K Apoptosis	Cancer
Apoptin-derived peptide is an antitumor polypeptide with cytotoxicity. Apoptin-derived peptide promotes apoptosis and necrosis of gastric cancer (GC) cells by regulating PI3K/AKT/ARNT signaling. Apoptin-derived peptide inhibited the invasion and migration of cancer cells, and inhibited the expression and phosphorylation of the subunit p85 of PI3K, which further inhibited the PI3K/AKT pathway involved in the development of gastric cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure